• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

147-24-0 (Diphenhydramine (hydrochloride))

1

Identification

Diphenhydramine (hydrochloride) Diphenhydramine (hydrochloride)
Name Diphenhydramine (hydrochloride)
Formula C17H22ClNO
MW 291.82
CAS No. 147-24-0
EINECS 205-687-2
Smiles CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl
Synonyms Benzhydramine hydrochloride; 2-(Benzhydryloxy)-N,N-dimethylethylamine hydrochloride; N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride; 2-(benzhydryloxy)-N,N-dimethylethanamine hydrochloride
InChI InChI=1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
2

Introduction

Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. Target: Histamine H1 receptor Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations.

Background Information

Diphenhydramine is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic and sedative properties which is mainly used to treat allergies. ......by AdooQ BioScience, LLC
Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. ......by BOC Sciences
Diphenhydramine is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties that is mainly used to treat allergies. It is also used in the management of drug-induced parkinsonism and other extrapyramidal symptoms. ......by MedKoo Biosciences, Inc.
Diphenhydramine hydrochloride is a histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects. ......by MedKoo Biosciences, Inc.
Diphenhydramine HCl is a first-generation histamine H1 receptor antagonist, used in various allergic conditions such as rhinitis, urticaria and conjunctivitis. ......by Selleck Chemicals LLC
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects. ......by Target Molecule Corp.
H1 receptor antagonist. Antihistamine. ......by Tocris Bioscience Inc.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012567

Storage condition

Desiccate at RT by Tocris Bioscience Inc.

Solubility

DMSO 58 mg/ml by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 58 mg/mL (198.75 mM); Water58 mg/mL (198.75 mM); Ethanol58 mg/mL (198.75 mM) by Selleck Chemicals LLC
Soluble to 100 mM in water by Tocris Bioscience Inc.
5

Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Diphenhydramine (hydrochloride) - Launched
7

Safety Data of Diphenhydramine (hydrochloride)

Hazard Symbols : Xn
Risk Statements : R22
Safety Statements : 36-45-36/37-16-7
RTECS : KR7000000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 250mg/USD60();500mg/USD72() USA
Cayman Chemical Company USA
Cayman Chemical Company USA
Choriway International Trade Co., Ltd. China
Freedom Chemical Supply USA
MedChemexpress Co., Ltd. 250mg/USD60();500mg/USD72() USA
MedKoo Biosciences, Inc. USA
MedKoo Biosciences, Inc. USA
Nanjing General Chemical Co., Ltd. China
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Dongyue Biochem Co., Ltd. China
Shanghai Haoyuan Chemexpress Co., Ltd. 250mg/USD60();500mg/USD72() China
Target Molecule Corp. 2mg/USD20();10mg/USD45();50mg/USD78();100mg/USD124() USA
Tocris Bioscience Inc. USA
Wujiang Mingheng Chemical Co., Ltd. China
10

Related Products

Other Forms of 147-24-0

Name CAS No Formula MW
Diphenhydramine 58-73-1 C17H21NO 255.35

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Diphenhydramine (hydrochloride)

Tags: buy 147-24-0 IC50 | 147-24-0 price | 147-24-0 cost | 147-24-0 solubility | 147-24-0 purchase | 147-24-0 manufacturer | 147-24-0 research buy | 147-24-0 order | 147-24-0 MSDS | 147-24-0 chemical structure | 147-24-0 Storage condition | 147-24-0 molecular weight | 147-24-0 mw | 147-24-0 datasheet | 147-24-0 supplier | 147-24-0 cell line | 147-24-0 NMR | 147-24-0 MS | 147-24-0 IR | 147-24-0 solubility | 147-24-0 Safe information | 147-24-0 Qc and Spectral Information | 147-24-0 Clinical Information | 147-24-0 Clinical Trial | 147-24-0 Route of Synthesis | 147-24-0 storage condition | 147-24-0 diseases and conditions | 147-24-0 flash point | 147-24-0 boiling point | 147-24-0 melting point | 147-24-0 storage condition | 147-24-0 brand