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93793-83-0 (Roxatidine (Acetate Hydrochloride))

1

Identification

Roxatidine (Acetate Hydrochloride) Roxatidine (Acetate Hydrochloride)
Name Roxatidine (Acetate Hydrochloride)
Formula C19H29ClN2O4
MW 384.9
CAS No. 93793-83-0
EINECS
Smiles O=C(NCCCOC1=CC=CC(CN2CCCCC2)=C1)COC(C)=O.Cl
Synonyms Roxit;Gastralgin;HOE 760; 2-oxo-2-((3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)amino)ethyl acetate hydrochloride
InChI InChI=1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23);1H
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Introduction

Roxatidine Acetate HCl is a specific and competitive histamin H2 receptor antagonist. Target: Histamin H2 Receptor Roxatidine acetate is a histamine H2-receptor antagonist which, after almost complete oral absorption (greater than 95%), is rapidly converted to its active metabolite, roxatidine, by esterases in the small intestine, plasma and liver.

Background Information

Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation. ......by AbMole BioScience
Roxatidine Acetate Hydrochloride is a histamine H2-receptor antagonist used in ulcer treatment. This compound has been found to inhibit platelet function in vitro. ......by AdooQ BioScience, LLC
Roxatidine Acetate HCl is a specific and competitive histamin H2 receptor antagonist. ......by BOC Sciences
Roxatidine Acetate Hydrochloride is a histamine H2-receptor antagonist used in ulcer treatment. This compound has been found to inhibit platelet function. ......by MedKoo Biosciences, Inc.
Roxatidine Acetate HCl is a specific and competitive histamin H2-receptor antagonist, with IC50 of 3.2 μM, inhibits gastric acid secretion and ulcer formation. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012565

Storage condition

Solubility

DMSO 78 mg/mL; Water 77 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 77 mg/mL (200.05 mM); Water77 mg/mL (200.05 mM); Ethanol12 mg/mL (31.17 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Roxatidine (Acetate Hydrochloride) - Launched
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Safety Data of Roxatidine (Acetate Hydrochloride)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD118();5g/USD336() USA
Cayman Chemical Company USA
Hangzhou Bm Chemical Co., Ltd. China
Langfang Gaobo Jingband Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 1g/USD118();5g/USD336() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD118();5g/USD336() China
Target Molecule Corp. 2mg/USD20();10mg/USD75();50mg/USD165();100mg/USD226() USA
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Related Products

Other Forms of 93793-83-0

Name CAS No Formula MW
Roxatidine Acetate 78628-28-1 C19H28N2O4 348.44

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Roxatidine (Acetate Hydrochloride)

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