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72509-76-3 (Felodipine)



Felodipine Felodipine
Name Felodipine
Formula C18H19Cl2NO4
MW 384.25
CAS No. 72509-76-3
Smiles O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC(Cl)=C2Cl)OCC
Synonyms Plendil;Renedil;Feloday; 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
InChI InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3


Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. Target: Calcium Channel Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b.

Background Information

Felodipine is an L-type (CaV1), voltage-gated Ca2+ channels are plasma membrane protein.Felodipine is a DHP that acts as L-type, voltage-gated Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. ......by Affix Scientific
Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. ......by BOC Sciences
A potent L-type Ca²⁺channel blocker that is selective over N-, R-, P/Q- and T-type channels. It displays high vascular selectivity over cardiac muscle, thus lowering arterial blood pressure without altering cardiac contractility. Felodipine is used in the clinic as an antihypertensive agent. ......by BioVision, Inc.,
Felodipine is a calcium channel blocker (calcium antagonist), used to control hypertension. Felodipine prevents calcium from being released within the muscle cells of the small arteries and thereby causes the muscles to relax and the arteries to dilate or expand. Dilation of arteries reduces blood pressure. Felodipine has little or no effect on the muscles of veins or the heart. Felodipine was approved by the FDA in 1991. ......by MedKoo Biosciences, Inc.
Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. ......by Selleck Chemicals LLC
A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. ......by Target Molecule Corp.
L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive. ......by Tocris Bioscience Inc.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Male Sprague-Dawley rats with approximately 5/6 renal ablation
Dosage 1 g/kg/day
Formulation Dissolved in DMSO, and diluted in saline
Administration Orally
Source Selleck Chemicals LLC

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000012560

Storage condition

Up to one week at 4°C or six months at -20°C. by Affix Scientific
Store at +4°C by Tocris Bioscience Inc.


DMSO 77 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 77 mg/mL (200.39 mM); Ethanol72 mg/mL (187.37 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 100 mM in DMSO and to 100 mM in ethanol by Tocris Bioscience Inc.

Mechanism and Indication

Signaling Pathways Membrane Transporter/Ion Channel
Target Calcium Channel
Research Area Cardiovascular Disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Felodipine - Launched

Safety Data of Felodipine

Hazard Symbols : Xn
Risk Statements : 22
Safety Statements : 36
RTECS : US7968700
WGKGermany : 3

Spectral Information


Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
Affix Scientific 1g/USD1660(In stock) USA
Anhui Modern Chem-Pharm Co., Ltd. China
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences 5g/USD298(In stock)
BioVision, Inc., USA
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD85();50mg/USD209() USA
Cayman Chemical Company USA
Changzhou Hengfeng Chemical Plant China
Changzhou Ruiming Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 10mg/USD85();50mg/USD209() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 10mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock);50mg/USD310(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD85();50mg/USD209() China
Target Molecule Corp. 2mg/USD36();10mg/USD65();50mg/USD165();100mg/USD268() USA
Tocris Bioscience Inc. USA
Zhejiang Wonderful Pharma & Chem Co., Ltd. China

Related Products

Other Forms of 72509-76-3

Name CAS No Formula MW

Recommended Compounds in Calcium Channel

Name CAS No Formula MW
Lercanidipine (hydrochloride) 132866-11-6 C36H42ClN3O6 648.19
Amlodipine (maleate) 88150-47-4 C24H29ClN2O9 524.9481
Lercanidipine 100427-26-7 C36H41N3O6 611.73
Neomycin (sulfate) 1405-10-3 C23H48N6O17S 712.72
Tetracaine (hydrochloride) 136-47-0 C15H25ClN2O2 300.82
Nitrendipine 39562-70-4 C18H20N2O6 360.36
Manidipine 89226-50-6 C35H38N4O6 610.7
Chlorpromazine (hydrochloride) 69-09-0 C17H20Cl2N2S 355.33
Ibutilide (fumarate) 122647-32-9 C44H76N4O10S2 885.23
Flunarizine (dihydrochloride) 30484-77-6 C26H28Cl2F2N2 477.42
Lacidipine 103890-78-4 C26H33NO6 455.54
Cromolyn (sodium) 15826-37-6 C23H14Na2O11 512.33
Amlodipine 88150-42-9 C20H25ClN2O5 408.88
Nifedipine 21829-25-4 C17H18N2O6 346.33
Acetylcholine (chloride) 60-31-1 C7H16ClNO2 181.6604
Ranolazine 95635-55-5 C24H33N3O4 427.54
Nimodipine 66085-59-4 C21H26N2O7 418.44
Isradipine 75695-93-1 C19H21N3O5 371.39
Zonisamide (sodium) 68291-98-5 C8H7N2NaO3S 234.21
Zonisamide 68291-97-4 C8H8N2O3S 212.23

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis



[1]. Johnson, J.D. and D.A. Fugman, Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther, 1983. 226(2): p. 330-4.

[2]. Rodler, S., et al., Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human vascular smooth muscle cells. J Mol Cell Cardiol, 1995. 27(10): p. 2295-302.

[3]. Yiu, S. and E.E. Knaus, Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem, 1996. 39(23): p. 4576-82.

Protocol Reference

Ljung (1990) Vascular selectivity of felodipine: experimental pharmacology. J.Cardiovasc.Pharmacol. 15 S11. PMID: 1693715.

Furukawa et al (1999) Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 291 464. PMID: 10525060.

Furukawa et al (2005) Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (α1G) expressed in Xenopus oocytes. J.Cardiovasc.Pharmacol. 45 241. PMID: