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76963-41-2 (Nizatidine)

1

Identification

Nizatidine Nizatidine
Name Nizatidine
Formula C12H21N5O2S2
MW 331.46
CAS No. 76963-41-2
EINECS
Smiles CN/C(NCCSCC1=CSC(CN(C)C)=N1)=C[N+]([O-])=O
Synonyms Axid; (E)-N-(2-(((2-((dimethylamino)methyl)thiazol-4-yl)methyl)thio)ethyl)-N-methyl-2-nitroethene-1,1-diamine
InChI InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3/b11-6+
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Introduction

Nizatidine is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. Target: Histamine H2 Receptor Nizatidine, a selective histamine H2-receptor antagonist, is a potent inhibitor of gastric acid secretion, with IC50 of 0.9 nM.

Background Information

Nizatidine?is a histamine H2-receptor antagonist with and IC50 of 6.7 nM for AChE. It inhibits stomach acid production, and commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). The relative anti-AChE potency was in the following order: neostigmine > nizatidine >cimetidine >> famotidine. The inhibition of AChE by nizatidine was noncompetitive, with a Ki value of 7.4 x 10 nM. Gastrointestinal (GI) motility was examined during the interdigestive state in dogs with chronically implanted force transducers. ......by AbMole BioScience
Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM. ......by BOC Sciences
Nizatidine is a histamine H2 receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. ......by MedKoo Biosciences, Inc.
Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM. ......by Selleck Chemicals LLC
A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Rat
Dosage 0.5-10 μmol/kg
Formulation saline
Administration s.c
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000012559

Storage condition

Solubility

DMSO 66 mg/mL; Water 30 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 66 mg/mL (199.11 mM); Water28 mg/mL (84.47 mM); Ethanol18 mg/mL (54.3 mM); In vivo Saline30 mg/mL by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Nizatidine - Launched
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Safety Data of Nizatidine

Hazard Symbols : Xn
Risk Statements : 22
Safety Statements : 36
RTECS : KM6565000
WGKGermany : 3
8

Spectral Information

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Suppliers List

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Related Products

Other Forms of 76963-41-2

Name CAS No Formula MW

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

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More Information

Nizatidine

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