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1508-75-4 (Tropicamide)



Tropicamide Tropicamide
Name Tropicamide
Formula C17H20N2O2
MW 284.35
CAS No. 1508-75-4
EINECS 216-140-2
Smiles O=C(N(CC)CC1=CC=NC=C1)C(CO)C2=CC=CC=C2
Synonyms N-Ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide; N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide
InChI InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3


Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist . Target: mAChR Tropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops.

Background Information

Tropicamide is an anticholinergic used as a mydriatic. ......by AdooQ BioScience, LLC
Tropicamide is a M4 selective muscarinic receptor antagonist, which shows a 3 fold selectivity for M4. Tropicamide produces short acting mydriasis and cycloplegia when applied as eye drops. ......by Affix Scientific
Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction. Tropicamide is a muscarini ......by BOC Sciences
Tropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4–8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye. ......by MedKoo Biosciences, Inc.
One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic. ......by Target Molecule Corp.
M4 selective muscarinic receptor antagonist. ......by Tocris Bioscience Inc.

Protocol(Only for Reference)

Cell Experiment

Animal Experiment


Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012546

Storage condition

Store at RT by Tocris Bioscience Inc.


DMSO 55 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 57 mg/mL (200.45 mM); Ethanol57 mg/mL (200.45 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
Soluble to 100 mM in DMSO by Tocris Bioscience Inc.

Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tropicamide - Launched

Safety Data of Tropicamide

Hazard Symbols : Xn
Risk Statements : R20/21/22;R36/37/38;R42/43
Safety Statements : S22;S26;S36
RTECS : CY1487860
WGKGermany : 3

Spectral Information


Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AdooQ BioScience, LLC USA
Affix Scientific 5g/USD1985(In stock) USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences
Beijing Merson Pharmaceutical Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD60();500mg/USD96() USA
Cayman Chemical Company USA
Haikou Lancent Industrial Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD60();500mg/USD96() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();500mg/USD96() China
Siwei Development Co., Ltd. China
Suzhou Sunray Pharmaceutical Co., Ltd. China
Target Molecule Corp. 2mg/USD20();10mg/USD74();50mg/USD141() USA
Tocris Bioscience Inc. USA
Zhongchang Chemical Co., Ltd. China

Related Products

Other Forms of 1508-75-4

Name CAS No Formula MW

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW

Route of Synthesis




More Information


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