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57381-26-7 (Irsogladine)

1

Identification

Irsogladine Irsogladine
Name Irsogladine
Formula C9H7Cl2N5
MW 256.09
CAS No. 57381-26-7
EINECS
Smiles NC1=NC(N)=NC(C2=CC(Cl)=CC=C2Cl)=N1
Synonyms Dicloguamine; 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine
InChI InChI=1S/C9H7Cl2N5/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7/h1-3H,(H4,12,13,14,15,16)
2

Introduction

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Target: PDE4; mACHR Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively.

Background Information

Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. It is a potent inhibitor of angiogenesis and protects MNNG-induced gastric carcinogenesis in rats. ......by AbMole BioScience
Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. ......by AdooQ BioScience, LLC
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mic ......by BOC Sciences
Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012540

Storage condition

Solubility

DMSO 2 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 2 mg/mL (7.8 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Irsogladine - Launched
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Safety Data of Irsogladine

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AbMole BioScience USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD66();500mg/USD180() USA
MedChemexpress Co., Ltd. 100mg/USD66();500mg/USD180() USA
Nanjing Boerkai Chemical Co., Ltd CHINA
Selleck Chemicals LLC 50mg/USD97(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD66();500mg/USD180() China
Target Molecule Corp. 100mg/USD52() USA
10

Related Products

Other Forms of 57381-26-7

Name CAS No Formula MW
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16

Recommended Compounds in Phosphodiesterase (PDE) mAChR

Name CAS No Formula MW
(R)-(-)-Rolipram 85416-75-7 C16H21NO3 275.34
Mirodenafil (dihydrochloride) 862189-96-6 C26H39Cl2N5O5S 604.59
Vardenafil (hydrochloride) 224785-91-5 C23H33ClN6O4S 525.06
Ibudilast 50847-11-5 C14H18N2O 230.31
Pentoxifylline 6493-05-6 C13H18N4O3 278.31
Anagrelide (hydrochloride) 58579-51-4 C10H8Cl3N3O 292.55
Vardenafil 224785-90-4 C23H32N6O4S 488.6
(S)-(+)-Rolipram 85416-73-5 C16H21NO3 275.34
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Dipyridamole (hydrochloride)(1:x) 35763-39-4 C24H41ClN8O4 541.09
Dipyridamole 58-32-2 C24H40N8O4 504.63
Pimobendan (hydrochloride) 77469-98-8 C19H19ClN4O2 370.83
Pimobendan 74150-27-9 C19H18N4O2 334.37
Aminophylline 317-34-0 C16H24N10O4 420.43
Diphylline 479-18-5 C10H14N4O4 254.24
Cilostazol 73963-72-1 C20H27N5O2 369.46
Deltarasin (hydrochloride) 1440898-82-7 C40H38ClN5O 640.22
Rolipram 61413-54-5 C16H21NO3 275.34
Deltarasin 1440898-61-2 C40H37N5O 603.75
Sildenafil (citrate) 171599-83-0 C28H38N6O11S 666.7

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

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More Information

Irsogladine

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