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155-41-9 (Methscopolamine (bromide))

1

Identification

Methscopolamine (bromide) Methscopolamine (bromide)
Name Methscopolamine (bromide)
Formula C18H24BrNO4
MW 398.29
CAS No. 155-41-9
EINECS 205-844-5
Smiles C[N+]1(C)[[email protected]@]2([H])[[email protected]](O3)([H])[[email protected]]3([H])[[email protected]]1([H])C[[email protected]](OC([[email protected]](CO)C4=CC=CC=C4)=O)C2.[Br-]
Synonyms (1R,2R,4S,5S,7s)-7-(((S)-3-hydroxy-2-phenylpropanoyl)oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide
InChI InChI=1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12-,13-,14-,15+,16-,17+;/m1./s1
2

Introduction

Methscopolamine (Pamine) is a muscarinic acetylcholine receptor blocker.

Background Information

Methscopolamine bromide is a competitive antimuscarinic agent that blocks the binding of acetylcholine at muscarinic acetylcholine receptors (mAChR M). ......by AdooQ BioScience, LLC
Methscopolamine is a muscarinic acetylcholine receptor blocker. ......by BOC Sciences
Methylscopolamine is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion. Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications. ......by MedKoo Biosciences, Inc.
A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012520

Storage condition

Solubility

DMSO 80 mg/mL; Water 80 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 79 mg/mL (198.34 mM); Water67 mg/mL (168.21 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Methscopolamine (bromide) - Launched
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Safety Data of Methscopolamine (bromide)

Hazard Symbols : T,N,Xn
Risk Statements : R20/21/22;R50/53
Safety Statements : S36/37;S60;S61
Transport Information : UN 1544
RTECS : YM3675000
WGKGermany : 3
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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Alfa Chemistry USA
Alkaloids Corporation India
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Boehringer Ingelheim GmbH Germany
CHEMSCENE, LLC 100mg/USD96();500mg/USD240() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 100mg/USD96();500mg/USD240() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD70(In stock);10mM/1mLIn DMSO/USD90(In stock);200mg/USD170(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD96();500mg/USD240() China
Target Molecule Corp. 10mg/USD24();50mg/USD82();100mg/USD153() USA
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Related Products

Other Forms of 155-41-9

Name CAS No Formula MW

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Methscopolamine (bromide)

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