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76824-35-6 (Famotidine)

1

Identification

Famotidine Famotidine
Name Famotidine
Formula C8H15N7O2S3
MW 337.45
CAS No. 76824-35-6
EINECS
Smiles N=C(NS(=O)(N)=O)CCSCC1=CSC(NC(N)=N)=N1
Synonyms Pepcid; 3-(((2-guanidinothiazol-4-yl)methyl)thio)-N-sulfamoylpropanimidamide
InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
2

Introduction

Famotidine is a competitive histamine H2-receptor antagonist.

Background Information

Famotidine is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions. ......by AbMole BioScience
Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. Unlike cimetidine, the first H2 antagonist, famotidine has no effect ......by BOC Sciences
Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. Unlike cimetidine, the first H2 antagonist, Famotidine has no effect on the cytochrome P450 enzyme system and does not appear to interact with other drugs. ......by MedKoo Biosciences, Inc.
A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012466

Storage condition

Solubility

DMSO 67 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 67 mg/mL (198.54 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Metabolic Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Famotidine - Launched
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Safety Data of Famotidine

Hazard Symbols : T
Risk Statements : 20/21/22-45-61
Safety Statements : 22-24/25-53-45-36/37/39
RTECS : UA2300000
WGKGermany : 2
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AbMole BioScience USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
Ark Pharm, Inc. USA
BLD Pharmatech
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD96();5g/USD288() USA
Cayman Chemical Company USA
Hubie Xinyuanshun Pharm&Chem Co., Ltd. China
Hunan Astar Bio-chemicals Technology Co., Ltd. China
Jiangsu Long Healthcare Limited China
MedChemexpress Co., Ltd. 1g/USD96();5g/USD288() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD96();5g/USD288() China
Shanghai Longschem Co., Ltd. China
Target Molecule Corp. 2mg/USD20();10mg/USD41();50mg/USD98();200mg/USD122() USA
Zhejiang Dongdong Pharmaceutical Co., Ltd. China
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Related Products

Other Forms of 76824-35-6

Name CAS No Formula MW

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Famotidine

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