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5908-99-6 (Atropine (sulfate monohydrate))

1

Identification

Atropine (sulfate monohydrate) Atropine (sulfate monohydrate)
Name Atropine (sulfate monohydrate)
Formula C34H50N2O11S
MW 694.83
CAS No. 5908-99-6
EINECS 200-235-0
Smiles O=S(O)(O)=O.O=C(C(C1=CC=CC=C1)CO)O[[email protected]]2C[[email protected]@H](CC3)N(C)[[email protected]@H]3C2.O=C(C(C4=CC=CC=C4)CO)O[[email protected]]5C[[email protected]@H](CC6)N(C)[[email protected]@H]6C5.O
Synonyms Atropine sulfate hydrate; (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate hemisulfate hydrate
InChI InChI=1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;
2

Introduction

Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist. Target: mAChR Atropine is a naturally occurring tropane alkaloid extracted from deadly nightshade (Atropa belladonna), Jimson weed (Datura stramonium), mandrake (Mandragora officinarum) and other plants of the family Solanaceae.

Background Information

Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery. ......by AbMole BioScience
Atropine is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. ......by AdooQ BioScience, LLC
Atropine is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 2.5 nM. ......by BOC Sciences
Atropine sulfate monohydrate is a competitive antagonist for the muscarinic acetylcholine receptor, used to decrease the production of saliva and secretions of the airway prior to surgery. ......by Selleck Chemicals LLC
Atropine is an antimuscarinic agent and has shown the pharmacological effects because of binding to muscarinic acetylcholine receptors. Atropine, the orthosteric antagonist, has been reported to compete with [3H]-NMS for all muscarinic subtypes with a potency consistent with the high affinities at the mAChR subtypes ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012409

Storage condition

Solubility

DMSO 140 mg/mL; Water 140 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 139 mg/mL (200.04 mM); Water139 mg/mL (200.04 mM); Ethanol139 mg/mL (200.04 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling Autophagy GPCR/G Protein
Target mAChR Autophagy
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Atropine (sulfate monohydrate) - Launched
7

Safety Data of Atropine (sulfate monohydrate)

Hazard Symbols : T+
Risk Statements : 26/28-43-36/37/38
Safety Statements : 23-45-36/37/39-26-1-25
HS Code : 29399900
RTECS : CK2455000
WGKGermany : 2
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Beijing Merson Pharmaceutical Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD60() USA
Emerald-Shanghai Incorporation CHINA
Henan PURUI Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD60() USA
Selleck Chemicals LLC 10mg/USD70(In stock);10mM/1mLIn DMSO/USD90(In stock);50mg/USD210(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60() China
Target Molecule Corp. 10mg/USD20();50mg/USD78();100mg/USD148() USA
Zhejiang Unipharma-Chem Co., Ltd. China
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Related Products

Other Forms of 5908-99-6

Name CAS No Formula MW
Atropine 51-55-8 C17H23NO3 289.37
Atropine sulfate 55-48-1 C34H48N2O10S 676.82

Recommended Compounds in mAChR Autophagy

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Atropine (sulfate monohydrate)

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