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65-29-2 (Gallamine Triethiodide)

1

Identification

Gallamine Triethiodide Gallamine Triethiodide
Name Gallamine Triethiodide
Formula C30H60I3N3O3
MW 891.53
CAS No. 65-29-2
EINECS 200-605-1
Smiles CC[N+](CC)(CC)CCOC(C(OCC[N+](CC)(CC)CC)=CC=C1)=C1OCC[N+](CC)(CC)CC.[I-].[I-].[I-]
Synonyms 2-[2,6-Bis(2-triethylazaniumylethoxy)phenoxy]ethyl-triethylazanium triiodide; 2,2',2''-(benzene-1,2,3-triyltris(oxy))tris(N,N,N-triethylethanaminium) iodide
InChI InChI=1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3
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Introduction

Gallamine Triethiodide is a synthetic nondepolarizing blocking drug. Target: mAChR Gallamine triethiodide is a non-depolarising muscle relaxant.

Background Information

Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. ......by AdooQ BioScience, LLC
Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM. It is is a non-depolarising muscle relaxant. ......by BOC Sciences
Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. It acts by combining with the cholinergic receptor sites in muscle and competitively blocks the transmitter action of acetylcholine. It is a synthetic non-depolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. ......by MedKoo Biosciences, Inc.
Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM. ......by Selleck Chemicals LLC
A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of TUBOCURARINE, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198) ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000012364

Storage condition

Solubility

DMSO 100 mg/mL; Water 100 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 100 mg/mL (112.16 mM); Water100 mg/mL (112.16 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Cardiovascular Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Gallamine Triethiodide - Launched
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Safety Data of Gallamine Triethiodide

Hazard Symbols : Xn
Risk Statements : R22;R36/37/38
Safety Statements : S26;S36;S45
RTECS : BS1100000
WGKGermany : 3
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
CHEMSCENE, LLC 100mg/USD72();500mg/USD132() USA
MedChemexpress Co., Ltd. 100mg/USD72();500mg/USD132() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD70(In stock);10mM/1mLIn DMSO/USD90(In stock);100mg/USD120(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD72();500mg/USD132() China
Target Molecule Corp. 10mg/USD36();50mg/USD81();100mg/USD142() USA
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Related Products

Other Forms of 65-29-2

Name CAS No Formula MW

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Gallamine Triethiodide

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