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10405-02-4 (Trospium (chloride))

1

Identification

Trospium (chloride) Trospium (chloride)
Name Trospium (chloride)
Formula C25H30ClNO3
MW 427.96
CAS No. 10405-02-4
EINECS 233-875-4
Smiles O=C(C(C1=CC=CC=C1)(O)C2=CC=CC=C2)O[[email protected]]3C[[email protected]]4([H])[N+]5(CCCC5)[[email protected]](CC4)([H])C3.[Cl-]
Synonyms (1R,3r,5S)-3-(2-hydroxy-2,2-diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-1'-ium chloride
InChI InChI=1S/C25H30NO3.ClH/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26;/h1-6,9-12,21-23,28H,7-8,13-18H2;1H/q+1;/p-1/t21-,22+,23+;
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Introduction

Trospium Chloride is a competitive muscarinic cholinergic receptor antagonist. Target: mAChR Trospium chloride is an antimuscarinic agent indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.

Background Information

Trospium chloride is a competitive muscarinic cholinergic receptor antagonist. ......by BOC Sciences
Trospium chloride is a muscarinic antagonist. Trospium chloride antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder. Receptor assays showed that trospium chloride has negligible affinity for nicotinic receptors as compared to muscarinic receptors at concentrations obtained from therapeutic doses. ......by MedKoo Biosciences, Inc.
Trospium is a urinary antispasmodic. It is sold under the brand name Sanctura in the US, and as Trosec in Canada. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012164

Storage condition

Solubility

DMSO 41 mg/mL; Water 85 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 41 mg/mL (95.8 mM); Water86 mg/mL (200.95 mM); Ethanol42 mg/mL (98.14 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Trospium (chloride) - Launched
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Safety Data of Trospium (chloride)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Beijing Mediking Biopharm Co., Ltd. China
Biochempartner Co., Ltd China
CHEMSCENE, LLC 50mg/USD180();100mg/USD300() USA
Cayman Chemical Company USA
Huaian Synniken Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 50mg/USD180();100mg/USD300() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 25mg/USD110(In stock);10mM/1mLIn DMSO/USD140(In stock);50mg/USD170(In stock);200mg/USD470(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD180();100mg/USD300() China
Target Molecule Corp. 5mg/USD37();25mg/USD78();50mg/USD144() USA
Zhejiang Dongdong Pharmaceutical Co., Ltd. China
Zhejiang Unipharma-Chem Co., Ltd. China
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Related Products

Other Forms of 10405-02-4

Name CAS No Formula MW

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Trospium (chloride)

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