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79307-93-0 (Azelastine (hydrochloride))

1

Identification

Azelastine (hydrochloride) Azelastine (hydrochloride)
Name Azelastine (hydrochloride)
Formula C22H25Cl2N3O
MW 418.36
CAS No. 79307-93-0
EINECS
Smiles O=C1N(C2CCN(C)CCC2)N=C(CC3=CC=C(Cl)C=C3)C4=C1C=CC=C4.Cl
Synonyms Astelin;Optivar;Allergodil;Rhinolast;Optilas; 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
InChI InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
2

Introduction

Azelastine HCl is a potent, second-generation, selective, histamine antagonist. Target: Histamine Receptor Azelastine is a selective H(1)-receptor antagonist that inhibits histamine release and interferes with activation of several other mediators of allergic inflammation.

Background Information

Azelastine hydrochloride (Astelin) is a potent, second-generation, selective, histamine antagonist. Azelastine hydrochloride (Astelin) has a triple mode of action: Anti-histamine effect, mast-cell stabilizing effect and anti-inflammatory effect. Azelastine hydrochloride (Astelin) has a rapid onset of action: 15 minutes with the nasal spray and 3 minutes with the eye drops. The effect lasts for 12 hours. ......by AbMole BioScience
Azelastine is a potent, second-generation, selective, histamine antagonist (histamine-H1-receptor antagonist). ......by AdooQ BioScience, LLC
Azelastine HCl is a potent, second-generation, selective, histamine antagonist. ......by BOC Sciences
Azelastine HCl is a potent and selective H1-receptor antagonist, with antiallergic effects related to histamine antagonism, and further antiallergic and anti-inflammatory effects unrelated to H1-receptor binding. Azelastine HCl is an activator of NF-kB activator. Azelastine hydrochloride has been used in a study to investigate the potential of polymeric microspheres for treatment of allergic conjunctivitis. Azelastine is shown to block secretion of IL-6, IL-8, and TNF alpha from mast cells by inhibiting NF-κB activation. ......by MedKoo Biosciences, Inc.
Azelastine HCl is a potent, second-generation, selective, histamine receptor antagonist, used in the treatment of rhinitis. ......by Selleck Chemicals LLC
Azelastine HCl is a potent, second-generation, selective, histamine antagonist. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012163

Storage condition

Solubility

DMSO 85 mg/mL; Water 35 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 84 mg/mL (200.78 mM); Ethanol84 mg/mL (200.78 mM); Water35 mg/mL (83.66 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Azelastine (hydrochloride) - Launched
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Safety Data of Azelastine (hydrochloride)

Hazard Symbols : Xn
Risk Statements : 22
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
AdooQ BioScience, LLC USA
Alfa Chemistry USA
Apexbio Technology LLC USA
BOC Sciences 1g/USD199(In stock)
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD50();200mg/USD69() USA
Cayman Chemical Company USA
Heta Pharm & Chem Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD50();200mg/USD69() USA
MedKoo Biosciences, Inc. USA
Nanjing Samwon International Limited China
Selleck Chemicals LLC 100mg/USD50(In stock);10mM/1mLIn DMSO/USD70(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD50();200mg/USD69() China
Shanghai Jinhuan Chemical Co., Ltd. China
Shanghai Luer Chemical Trading Co., Ltd CHINA
Target Molecule Corp. 2mg/USD20();10mg/USD75();50mg/USD268() USA
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Related Products

Other Forms of 79307-93-0

Name CAS No Formula MW
Azelastine 58581-89-8 C22H24ClN3O 381.9

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Azelastine (hydrochloride)

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