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980-71-2 (Brompheniramine (maleate))

1

Identification

Brompheniramine (maleate) Brompheniramine (maleate)
Name Brompheniramine (maleate)
Formula C20H23BrN2O4
MW 435.31
CAS No. 980-71-2
EINECS 213-562-9
Smiles CN(CCC(C1=CC=C(Br)C=C1)C2=NC=CC=C2)C.O=C(O)/C=CC(O)=O
Synonyms 1-p-Bromophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate; 1-(N,N-Dimethylamino)-3-(p-bromophenyl)-3-(alpha-pyridyl)propane maleate; 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate
InChI InChI=1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
2

Introduction

Brompheniramine maleate is a histamine H1 receptors antagonist. Target: Histamine H1 Receptor Brompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class.

Background Information

Brompheniramine is a histamine H1 receptors antagonist. Brompheniramine also functions as a moderately effective anticholinergic agent, and is likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. Brompheniramine is an antihistamine compound of the propylamine (alkylamine) class. Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin.Brompheniramine also has analgesic-sparing (potentiating) effects on opioid analgesics, commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 percent. Brompheniramine is metabolised by cytochrome P450s. ......by AbMole BioScience
Brompheniramine is a first-generation antihistamine. Brompheniramine works by acting as an antagonist of histamine H1 receptors. It also functions as a moderately effective anticholinergic agent, and is likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. ......by AdooQ BioScience, LLC
Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist. ......by BOC Sciences
Brompheniramine, commonly marketed as its salt brompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine. Brompheniramine works by acting as an antagonist of histamine H1 receptors. It also functions as a moderately effective anticholinergic agent, and is likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. ......by MedKoo Biosciences, Inc.
Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000012144

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 87 mg/mL (199.85 mM); Water46 mg/mL warming (105.67 mM); Ethanol18 mg/mL (41.34 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Brompheniramine (maleate) - Launched
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Safety Data of Brompheniramine (maleate)

Hazard Symbols : Xi
Risk Statements : R22
Safety Statements : S36
RTECS : US4025000
WGKGermany : 3
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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
AdooQ BioScience, LLC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
Boehringer Ingelheim GmbH Germany
CHEMSCENE, LLC 50mg/USD84();100mg/USD120() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 50mg/USD84();100mg/USD120() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD84();100mg/USD120() China
Target Molecule Corp. 10mg/USD20();50mg/USD84();100mg/USD157() USA
Zhejiang Ouhua Chemical Imp. & Exp. Co., Ltd. China
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Related Products

Other Forms of 980-71-2

Name CAS No Formula MW
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.3116

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Brompheniramine (maleate)

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