• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

300-08-3 (Arecoline (hydrobromide))

1

Identification

Arecoline (hydrobromide) Arecoline (hydrobromide)
Name Arecoline (hydrobromide)
Formula C8H14BrNO2
MW 236.11
CAS No. 300-08-3
EINECS 206-087-3
Smiles O=C(OC)C1=CCCN(C)C1.Br
Synonyms Methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide; methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide
InChI InChI=1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
2

Introduction

Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.

Background Information

Arecoline is a muscarinic acetylcholine receptor agonist. ......by BOC Sciences
Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC₅₀ = 11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1 – M5 (EC₅₀ in the range of 7-410 nM). May be effective in dementia. ......by BioVision, Inc.,
Arecoline Hydrobromide is a muscarinic and nicotinic acetylcholine receptor agonist. Results indicate that the effect of arecoline on rat hepaticdoes not involve transcriptional activation of the gene, but largely involves the stabilization of CYP2E1 protein against degradation or increased efficiency of CYP2E1 mRNA translation, and additionally involve the post- ranslational modification of CYP2E1 protein. Furthermore, the CYP2E1 response is fairly equal among the different species, the induction of rat hepatic CYP2E1 by arecoline suggests that there is a risk of metabolic interaction among the substrate drugs of CYP2E1 in betel-quid use human. ......by MedKoo Biosciences, Inc.
Arecoline is a muscarinic acetylcholine receptor agonist. ......by Selleck Chemicals LLC
Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:Light yellow to yellow Solid EBNumber:EB000012135

Storage condition

Solubility

DMSO 47 mg/mL; Water 47 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 47 mg/mL (199.05 mM); Water47 mg/mL (199.05 mM); Ethanol10 mg/mL (42.35 mM) by Selleck Chemicals LLC
5

Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Arecoline (hydrobromide) - Launched
7

Safety Data of Arecoline (hydrobromide)

Hazard Symbols : Xn
Risk Statements : R22
Safety Statements : 45-38-36/37/39-28A
HS Code : 29399990
RTECS : QT2275000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AOBIOUS INC USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
Atlantic Research Chemicals Ltd.
BLD Pharmatech
BOC Sciences
BioVision, Inc., USA
Biochempartner Co., Ltd China
Boehringer Ingelheim GmbH Germany
CHEMSCENE, LLC 500mg/USD60();1g/USD96() USA
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 500mg/USD60();1g/USD96() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 500mg/USD60();1g/USD96() China
Target Molecule Corp. 5mg/USD24();10mg/USD45();20mg/USD67();100mg/USD177();250mg/USD329() USA
10

Related Products

Other Forms of 300-08-3

Name CAS No Formula MW

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Arecoline (hydrobromide)

Tags: buy 300-08-3 IC50 | 300-08-3 price | 300-08-3 cost | 300-08-3 solubility | 300-08-3 purchase | 300-08-3 manufacturer | 300-08-3 research buy | 300-08-3 order | 300-08-3 MSDS | 300-08-3 chemical structure | 300-08-3 Storage condition | 300-08-3 molecular weight | 300-08-3 mw | 300-08-3 datasheet | 300-08-3 supplier | 300-08-3 cell line | 300-08-3 NMR | 300-08-3 MS | 300-08-3 IR | 300-08-3 solubility | 300-08-3 Safe information | 300-08-3 Qc and Spectral Information | 300-08-3 Clinical Information | 300-08-3 Clinical Trial | 300-08-3 Route of Synthesis | 300-08-3 storage condition | 300-08-3 diseases and conditions | 300-08-3 flash point | 300-08-3 boiling point | 300-08-3 melting point | 300-08-3 storage condition | 300-08-3 brand