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| Smiles | O=C(OC)C1=CCCN(C)C1.Br |
|---|---|
| Synonyms | Methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide; methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide |
| InChI | InChI=1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H |
Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.
| Arecoline is a muscarinic acetylcholine receptor agonist. ......by BOC Sciences |
| Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC₅₀ = 11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1 – M5 (EC₅₀ in the range of 7-410 nM). May be effective in dementia. ......by BioVision, Inc., |
| Arecoline Hydrobromide is a muscarinic and nicotinic acetylcholine receptor agonist. Results indicate that the effect of arecoline on rat hepaticdoes not involve transcriptional activation of the gene, but largely involves the stabilization of CYP2E1 protein against degradation or increased efficiency of CYP2E1 mRNA translation, and additionally involve the post- ranslational modification of CYP2E1 protein. Furthermore, the CYP2E1 response is fairly equal among the different species, the induction of rat hepatic CYP2E1 by arecoline suggests that there is a risk of metabolic interaction among the substrate drugs of CYP2E1 in betel-quid use human. ......by MedKoo Biosciences, Inc. |
| Arecoline is a muscarinic acetylcholine receptor agonist. ......by Selleck Chemicals LLC |
| Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist. ......by Target Molecule Corp. |
| Appearance:Light yellow to yellow Solid | EBNumber:EB000012135 |
| DMSO 47 mg/mL; Water 47 mg/mL | by MedChemexpress Co., Ltd. |
| (25°C) * In vitro DMSO 47 mg/mL (199.05 mM); Water47 mg/mL (199.05 mM); Ethanol10 mg/mL (42.35 mM) | by Selleck Chemicals LLC |
| Signaling Pathways | Neuronal Signaling | GPCR/G Protein |
|---|
| Target | mAChR |
|---|
| Research Area | Neurological Disease |
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| Indications |
|---|
| Product Name | Sponsor & Collaborators | Indications | Start Date | End Date | Phase |
|---|---|---|---|---|---|
| Arecoline (hydrobromide) | - | Launched |
| Hazard Symbols : Xn |
| Risk Statements : R22 |
| Safety Statements : 45-38-36/37/39-28A |
| HS Code : 29399990 |
| RTECS : QT2275000 |
| WGKGermany : 3 |
| Company | Price and Availability | Country/Region |
|---|---|---|
| AA Blocks LLC | ||
| AOBIOUS INC | USA | |
| Apexbio Technology LLC | USA | |
| Ark Pharm, Inc. | USA | |
| Atlantic Research Chemicals Ltd. | ||
| BLD Pharmatech | ||
| BOC Sciences | ||
| BioVision, Inc., | USA | |
| Biochempartner Co., Ltd | China | |
| Boehringer Ingelheim GmbH | Germany | |
| CHEMSCENE, LLC | 500mg/USD60();1g/USD96() | USA |
| Cayman Chemical Company | USA | |
| MedChemexpress Co., Ltd. | 500mg/USD60();1g/USD96() | USA |
| MedKoo Biosciences, Inc. | USA | |
| Selleck Chemicals LLC | 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) | USA |
| Shanghai Haoyuan Chemexpress Co., Ltd. | 500mg/USD60();1g/USD96() | China |
| Target Molecule Corp. | 5mg/USD24();10mg/USD45();20mg/USD67();100mg/USD177();250mg/USD329() | USA |
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