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132-17-2 (Benztropine (mesylate))

1

Identification

Benztropine (mesylate) Benztropine (mesylate)
Name Benztropine (mesylate)
Formula C22H29NO4S
MW 403.54
CAS No. 132-17-2
EINECS 205-048-8
Smiles CN1[[email protected]@]2([H])C[[email protected]@H](C[[email protected]]1([H])CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4.CS(O)(=O)=O
Synonyms Endo-3-(diphenylmethoxy)-8-methyl-8-azoniabicyclo[3.2.1]octane methanesulphonate; (1R,3r,5S)-3-(benzhydryloxy)-8-methyl-8-azabicyclo[3.2.1]octane methanesulfonate
InChI InChI=1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+;
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Introduction

Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease. Target: mAChR Benzotropine is a centrally-acting, antimuscarinic agent used as an adjunct in the treatment of Parkinson's disease.

Background Information

An anticholinergic drug used in patients to reduce the side effects of antipsychotic treatment and a second-line drug for the treatment of Parkinson's disease ......by AOBIOUS INC
Benztropine inhibits MTSET-induced inhibition of [3H]WIN binding to Wild-type dopamine transporter with EC50 of 28 μM in concentration-dependent manner. ......by BOC Sciences
Benztropine is a synthetic compound derived from the combination of atropine and diphenhydramine that acts centrally to antagonize M1 muscarinic acetylcholine receptors. Benztropine has been used in the management of Parkinson’s disease symptoms to address involuntary tremor and dystonia. It can also increase the availability of dopamine by inhibiting uptake through the dopamine transporter. ......by MedKoo Biosciences, Inc.
Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM. ......by Selleck Chemicals LLC
Benzatropine is an anticholinergic drug used in patients to reduce the side effects of antipsychotic treatment. Benzatropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor, but not rigidity and bradykinesia. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011999

Storage condition

Solubility

DMSO 50 mg/mL; Water 80 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 50 mg/mL (123.9 mM); Water81 mg/mL (200.72 mM); Ethanol81 mg/mL (200.72 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Benztropine (mesylate) - Launched
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Safety Data of Benztropine (mesylate)

Hazard Symbols : T
Risk Statements : R23/24/25
Safety Statements : S36/37/39;S45
Transport Information : UN 2811
RTECS : YM3150000
WGKGermany : 3
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AOBIOUS INC 1mg/USD9() USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Beijing Merson Pharmaceutical Co., Ltd. China
CHEMSCENE, LLC 1g/USD60() USA
Cambridge Isotope Laboratories, Inc. USA
Carbosynth Limited
Cayman Chemical Company USA
MedChemexpress Co., Ltd. 1g/USD60() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD200(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD60() China
Target Molecule Corp. 2mg/USD20();10mg/USD68();50mg/USD140();200mg/USD260() USA
Zhongchang Chemical Co., Ltd. China
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Related Products

Other Forms of 132-17-2

Name CAS No Formula MW
Benzatropine 86-13-5 C21H25NO 307.43

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Benztropine (mesylate)

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