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5579-84-0 (Betahistine (dihydrochloride))

1

Identification

Betahistine (dihydrochloride) Betahistine (dihydrochloride)
Name Betahistine (dihydrochloride)
Formula C8H14Cl2N2
MW 209.12
CAS No. 5579-84-0
EINECS 226-966-5
Smiles CNCCC1=CC=CC=N1.Cl.Cl
Synonyms Veserc;Serc;Hiserk;Betaserc; N-methyl-2-(pyridin-2-yl)ethanamine dihydrochloride
InChI InChI=1S/C8H12N2.2ClH/c1-9-7-5-8-4-2-3-6-10-8;;/h2-4,6,9H,5,7H2,1H3;2*1H
2

Introduction

Betahistine Dihydrochloride is a histamine H3 receptors inhibitor used as an antivertigo drug. Target: Histamine Receptor Betahistine, a structural analogue of histamine with weak histamine H(1) receptor agonist and more potent H(3) receptor antagonist properties.

Background Information

Betahistine is a histamine H3 receptors inhibitor with IC50 of 1.9 μM. ......by AbMole BioScience
Betahistine is a histamine H3 receptors inhibitor with IC50 of 1.9 μM. ......by BOC Sciences
Betahistine dihydrochloride is an anti-vertigo drug. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms associated with Ménière's disease. It was first registered in Europe in 1970 for the treatment of Ménière's disease. ......by MedKoo Biosciences, Inc.
Betahistine is a histamine H3 receptor inhibitor with IC50 of 1.9 μM. ......by Selleck Chemicals LLC
Betahistine is an antivertigo drug first used for treating vertigo assosicated with Ménière’s disease. It is also commonly used for patients with balance disorders. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011992

Storage condition

Solubility

DMSO 38 mg/mL; Water 38 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 38 mg/mL (181.71 mM); Water38 mg/mL (181.71 mM); Ethanol1 mg/mL (4.78 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Betahistine (dihydrochloride) - Launched
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Safety Data of Betahistine (dihydrochloride)

Safety Statements : 24/25
RTECS : UT2969000
WGKGermany : 3
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AbMole BioScience USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
Astatech, Inc. USA
BLD Pharmatech
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 1g/USD60();5g/USD84() USA
Changzhou Xinhua Chemical Product Co., Ltd CHINA
Hangzhou Starshine Pharmaceutical Co., Ltd. China
MedChemexpress Co., Ltd. 1g/USD60();5g/USD84() USA
MedKoo Biosciences, Inc. USA
Qufu Haida Tiancheng Biochemical Co., Ltd. China
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD60();5g/USD84() China
Shenzhen Fangye Industries Co., Ltd. China
Target Molecule Corp. 2mg/USD20();10mg/USD44();50mg/USD70();100mg/USD122() USA
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Related Products

Other Forms of 5579-84-0

Name CAS No Formula MW
Betahistine 5638-76-6 C8H12N2 136.19

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Betahistine (dihydrochloride)

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