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322-79-2 (Triflusal)

1

Identification

Triflusal Triflusal
Name Triflusal
Formula C10H7F3O4
MW 248.16
CAS No. 322-79-2
EINECS 206-297-5
Smiles OC(C1=CC=C(C(F)(F)F)C=C1OC(C)=O)=O
Synonyms 2-Acetoxy-4-trifluoromethylbenzoic acid; 2-acetoxy-4-(trifluoromethyl)benzoic acid
InChI InChI=1S/C10H7F3O4/c1-5(14)17-8-4-6(10(11,12)13)2-3-7(8)9(15)16/h2-4H,1H3,(H,15,16)
2

Introduction

Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1. Target: COX Triflusal at 10 mM, 100 mM and 1 M decreases LDH efflux in rat brain slices after anoxia/reoxygenation by 24%, 35% and 49% respectively.

Background Information

Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1. ......by AbMole BioScience
Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1. ......by BOC Sciences
Triflusal is a platelet aggregation inhibitor. It is a drug of the salicylate family but it is not a derivative of acetylsalicylic acid (ASA). Triflusal is indicated for the prevention of cardiovascular events such as stroke, acute treatment of cerebral infarction and myocardial infarction, and thromboprophylaxis due to atrial fibrillation. ......by MedKoo Biosciences, Inc.
Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1. ......by Selleck Chemicals LLC
Triflusal is a platelet aggregation inhibitor that was discovered and developed in the Uriach Laboratories, and commercialised in Spain since 1981. Currently, it is available in 25 countries in Europe, Asia, Africa and America. It is a drug of the salicylate family but it is not a derivative of acetylsalicylic acid (ASA). ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011979

Storage condition

Solubility

DMSO 50 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 50 mg/mL (201.48 mM); Ethanol50 mg/mL (201.48 mM); Water<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation
Target COX
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Triflusal - Launched
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Safety Data of Triflusal

Hazard Symbols : Xn
Risk Statements : 22-36/37/38-43
Safety Statements : 26-36/37
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AbMole BioScience USA
Alfa Chemistry USA
Apexbio Technology LLC USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 5mg/USD72();10mg/USD120() USA
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd. China
Hefei Topway Biotechnology Co., Ltd. China
MedChemexpress Co., Ltd. 5mg/USD72();10mg/USD120() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 5mg/USD70(In stock);10mM/1mLIn DMSO/USD80(In stock);10mg/USD110(In stock);25mg/USD270(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 5mg/USD72();10mg/USD120() China
Suzhou Huihe Pharm Co., Ltd. China
Target Molecule Corp. 10mg/USD73();50mg/USD168();100mg/USD294() USA
Wuhan Haizheng Industry & Trade Development Co., Ltd. China
ZONK Drug R&D Limited China
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Related Products

Other Forms of 322-79-2

Name CAS No Formula MW
Triflusal (sodium salt) 74626-40-7 C10H6F3NaO4 270.14

Recommended Compounds in COX

Name CAS No Formula MW
Isoorientin 4261-42-1 C21H20O11 448.3769
Maslinic acid 4373-41-5 C30H48O4 472.7
Aceclofenac 89796-99-6 C16H13Cl2NO4 354.18
Zaltoprofen 74711-43-6 C17H14O3S 298.36
Ketorolac 74103-06-3 C15H13NO3 255.27
Loxoprofen 68767-14-6 C15H18O3 246.3
Mefenamic acid 61-68-7 C15H15NO2 241.29
Nabumetone 42924-53-8 C15H16O2 228.29
Diclofenac (diethylamine) 78213-16-8 C18H22Cl2N2O2 369.29
Bufexamac 2438-72-4 C12H17NO3 223.27
Acemetacin 53164-05-9 C21H18ClNO6 415.82
Phenacetin 62-44-2 C10H13NO2 179.22
Tenoxicam 59804-37-4 C13H11N3O4S2 337.37
Flunixin (meglumine) 42461-84-7 0.0
Lornoxicam 70374-39-9 C13H10ClN3O4S2 371.82
Nimesulide 51803-78-2 C13H12N2O5S 308.31
Tolfenamic Acid 13710-19-5 C14H12ClNO2 261.7
Fenoprofen (Calcium) 34597-40-5 C30H26CaO6 522.6
Deracoxib 169590-41-4 C17H14F3N3O3S 397.37
Meloxicam 71125-38-7 C14H13N3O4S2 351.4

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Triflusal

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