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100299-08-9 (Pemirolast (potassium))

1

Identification

Pemirolast (potassium) Pemirolast (potassium)
Name Pemirolast (potassium)
Formula C10H7KN6O
MW 266.3
CAS No. 100299-08-9
EINECS
Smiles O=C1C(C2=N[N-]N=N2)=CN=C3N1C=CC=C3C.[K+]
Synonyms BMY26517;TWT-8152;BMY 26517;BMY-26517;TWT8152;TWT 8152; potassium 5-(9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)tetrazol-2-ide
InChI InChI=1S/C10H7N6O.K/c1-6-3-2-4-16-9(6)11-5-7(10(16)17)8-12-14-15-13-8;/h2-5H,1H3;/q-1;+1
2

Introduction

Pemirolast Potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. Target: Histamine H1 Receptor Pemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma [1].

Background Information

Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. ......by AbMole BioScience
Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. ......by BOC Sciences
Pemirolast potassium, also known as BMY 26517, is a potent histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. It has also been studied for the treatment of asthma. Pemirolast potently attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides in rats. Pemirolast reduces cisplatin-induced kaolin intake in rats. ......by MedKoo Biosciences, Inc.
Pemirolast potassium (BMY 26517) is a histamine H1 antagonist and mast cell stabilizer that acts as an antiallergic agent. ......by Selleck Chemicals LLC
Pemirolast potassium is a slightly yellow powder that is soluble in water. It is a mast cell stabilizer that acts as an antiallergic agent. As an ophthalmic aqueous sterile solution, pemirolast is used for the prevention of itching of the eyes caused by allergies such as hay fever, and allergic conjunctivitis. Pemirolast is potentially useful for prophylaxis of pulmonary hypersensitivity reactions to drugs such as paclitaxel. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:light yellow to green yellow Solid EBNumber:EB000011960

Storage condition

Solubility

DMSO <1 mg/mL; Water 50 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro Water 53 mg/mL (199.02 mM); DMSO<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Pemirolast (potassium) - Launched
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Safety Data of Pemirolast (potassium)

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AbMole BioScience USA
Apexbio Technology LLC USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 10mg/USD66();50mg/USD204() USA
Cayman Chemical Company USA
Intatrade Chemicals GmbH
MedChemexpress Co., Ltd. 10mg/USD66();50mg/USD204() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 10mg/USD147(In stock);50mg/USD370(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 10mg/USD66();50mg/USD204() China
Target Molecule Corp. 2mg/USD46();10mg/USD92();50mg/USD164();100mg/USD266() USA
Yangzhou Lianhuan Pharmaceutical Co., Ltd. China
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Related Products

Other Forms of 100299-08-9

Name CAS No Formula MW

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Pemirolast (potassium)

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