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100643-71-8 (Desloratadine)

1

Identification

Desloratadine Desloratadine
Name Desloratadine
Formula C19H19ClN2
MW 310.82
CAS No. 100643-71-8
EINECS
Smiles ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1
Synonyms Clarinex;Neoclarityn;Sch34117; 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
InChI InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
2

Introduction

Desloratadine(Sch34117) is a potent antagonist for human histamine H1 receptor used to treat allergies. Target: Histamine H1 Receptor Desloratadine binds to the human H1 receptor with Ki value of 0.87 nM in displacing tritiated mepyramine.

Background Information

Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM. ......by AbMole BioScience
Desloratadine is a tricyclic H1-antihistamine that is used to treat allergies. It is an active metabolite of loratadine. Desloratadine is a selective H1-antihistamine which functions as an inverse agonist at the histamine H1 receptor; it is also an antagonist at all subtypes of the muscarinic acetylcholine receptors. It has a long-lasting effect and in moderate and low doses. It exhibits only peripheral activity since it does not readily cross the blood-brain barrier; hence, it does not cause drowsiness because it does not readily enter the central nervous system. (Source: https://en.wikipedia.org/wiki/Desloratadine). ......by MedKoo Biosciences, Inc.
Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM. ......by Selleck Chemicals LLC
Desloratadine is a potent antagonist for human histamine H1 receptor with IC50 of 51 nM. ......by Target Molecule Corp.
High affinity histamine H1 receptor antagonist (Ki = 0.87 nM); active metabolite of loratadine (Cat. No. 1944). Anti-inflammatory. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Male guinea-pigs
Dosage 10 mg/kg
Formulation 20% polyethylene glycol-300
Administration Subcutaneous
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011959

Storage condition

Solubility

DMSO 26 mg/mL; Water <1 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 26 mg/mL (83.64 mM); Ethanol62 mg/mL (199.47 mM); Water<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W30 mg/mL by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Desloratadine - Launched
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Safety Data of Desloratadine

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
AbMole BioScience USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BLD Pharmatech
Biochempartner Co., Ltd China
Brook Chemical Limited China
CHEMSCENE, LLC 50mg/USD60();100mg/USD84() USA
Cayman Chemical Company USA
Hainan Poly Pharm Co., Ltd. China
JACX Chemical Co., Ltd. China
Jushin Chem (Ningbo) Co., Ltd. China
MedChemexpress Co., Ltd. 50mg/USD60();100mg/USD84() USA
MedKoo Biosciences, Inc. USA
Selleck Chemicals LLC 10mg/USD110(In stock);10mM/1mLIn DMSO/USD140(In stock);50mg/USD370(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD60();100mg/USD84() China
Shenzhen Salubris Pharmaceuticals Co., Ltd. China
Target Molecule Corp. 10mg/USD95();50mg/USD246();100mg/USD369() USA
Tocris Bioscience Inc. USA
Wenling Tongda Fine Chemical Co., Ltd CHINA
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Related Products

Other Forms of 100643-71-8

Name CAS No Formula MW

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Desloratadine

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