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51-56-9 (Homatropine (Bromide))

1

Identification

Homatropine (Bromide) Homatropine (Bromide)
Name Homatropine (Bromide)
Formula C16H22BrNO3
MW 356.25
CAS No. 51-56-9
EINECS 200-105-3
Smiles O=C(C(O)C1=CC=CC=C1)O[[email protected]]2C[[email protected]](CC3)([H])N(C)[[email protected]]3([H])C2.Br
Synonyms alpha-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide; (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-hydroxy-2-phenylacetate hydrobromide
InChI InChI=1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H/t12-,13+,14+,15?;
2

Introduction

Homatropine Bromide is muscarinic AChR antagonist that is an anticholinergic medication. Target: mAChR Homatropine is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system.

Background Information

Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. ......by BOC Sciences
Homatropine Bromide is an muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. ......by Selleck Chemicals LLC
Homatropine Bromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Sprague-Dawley rats
Dosage 20 mg/kg
Formulation Saline
Administration Intramuscular (IM) injections
Source Selleck Chemicals LLC
4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011949

Storage condition

Solubility

DMSO 70 mg/mL; Water 70 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 71 mg/mL (199.29 mM); Water71 mg/mL (199.29 mM); Ethanol<1 mg/mL (<1 mM) by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Homatropine (Bromide) - Launched
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Safety Data of Homatropine (Bromide)

Hazard Symbols : T
Risk Statements : R23/24/25
Safety Statements : S24/25;S45
RTECS : YM5602000
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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
Acros Organics Belgium
Alfa Chemistry USA
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Beijing Merson Pharmaceutical Co., Ltd. China
CHEMSCENE, LLC 1g/USD60();5g/USD108() USA
Changzhou Lanling Chemical Co., Ltd. China
Discovery Fine Chemicals Ltd.
MedChemexpress Co., Ltd. 1g/USD60();5g/USD108() USA
Selleck Chemicals LLC 50mg/USD97(In stock);10mM/1mLIn DMSO/USD130(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 1g/USD60();5g/USD108() China
Target Molecule Corp. 2mg/USD20();10mg/USD86();50mg/USD264() USA
Zhongchang Chemical Co., Ltd. China
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Related Products

Other Forms of 51-56-9

Name CAS No Formula MW
Homatropine 87-00-3 C16H21NO3 275.34

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Homatropine (Bromide)

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