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3717-88-2 (Flavoxate (hydrochloride))

1

Identification

Flavoxate (hydrochloride) Flavoxate (hydrochloride)
Name Flavoxate (hydrochloride)
Formula C24H26ClNO4
MW 427.92
CAS No. 3717-88-2
EINECS 223-066-4
Smiles O=C1C2=C(OC(C3=CC=CC=C3)=C1C)C(C(OCCN4CCCCC4)=O)=CC=C2.Cl
Synonyms 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester hydrochloride; 2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate hydrochloride
InChI InChI=1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H
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Introduction

Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic. Target: mAChR Flavoxate displaces [3H]nitrendipine on the Ca2+ channels binding sites with IC50 of 254 μM [1].

Background Information

Parasympatholytic agent with antispasmodic activity, competitively binding to muscarinic receptors and preventing the actions of acetylcholine ......by AOBIOUS INC
Flavoxate is an anticholinergic with antimuscarinic effects. Its muscle relaxant properties may be due to a direct action on the smooth muscle rather than by antagonizing muscarinic receptors. ......by BOC Sciences
Flavoxate HCl is a parasympatholytic agent with antispasmodic activity, competitively binding to muscarinic receptors and preventing the actions of acetylcholine. ......by MedKoo Biosciences, Inc.
Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM. ......by Selleck Chemicals LLC
A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

Animal Models Sprague-Dawley rats
Dosage 10 mg/kg
Formulation Saline
Administration Intravenous
Source Selleck Chemicals LLC
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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011945

Storage condition

Solubility

DMSO 3 mg/mL; Water 10 mg/mL by MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 3 mg/mL (7.01 mM); Water10 mg/mL (23.36 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W30 mg/mL by Selleck Chemicals LLC
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Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Flavoxate (hydrochloride) - Launched
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Safety Data of Flavoxate (hydrochloride)

Hazard Symbols : Xn
Risk Statements : R22;R36/37/38
Safety Statements : S26
RTECS : DJ2450000
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 3717-88-2

Name CAS No Formula MW
Flavoxate 15301-69-6 C24H25NO4 391.46

Recommended Compounds in mAChR

Name CAS No Formula MW
Pilocarpine (Hydrochloride) 54-71-7 C11H17ClN2O2 244.72
Imidafenacin 170105-16-5 C20H21N3O 319.4
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Flavoxate (hydrochloride)

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