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80012-43-7 (Epinastine)

1

Identification

Epinastine Epinastine
Name Epinastine
Formula C16H15N3
MW 249.31
CAS No. 80012-43-7
EINECS
Smiles NC1=NCC2N1C3=CC=CC=C3CC4=CC=CC=C24
Synonyms Elestat;WAL801; 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
InChI InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18)
2

Introduction

Epinastine(WAL801) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. Target: Histamine Receptor Epinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum.

Background Information

Epinastine(WAL801) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. ......by AbMole BioScience
Epinastine is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is highly selective for the H1 receptor and does not cross the blood-brain-barrier. It shows a high affinity to H1-rece ......by BOC Sciences
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011812

Storage condition

Solubility

DMSO 57 mg/mL; Water 57 mg/mL by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Epinastine - Launched
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Safety Data of Epinastine

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Spectral Information

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Suppliers List

Company Price and Availability Country/Region
AbMole BioScience USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 50mg/USD96();100mg/USD132() USA
Hangzhou Deli Chemical Co., Ltd. China
MedChemexpress Co., Ltd. 50mg/USD96();100mg/USD132() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 50mg/USD96();100mg/USD132() China
Xiamen Kaijia Imp & Exp Co., Ltd. China
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Related Products

Other Forms of 80012-43-7

Name CAS No Formula MW
Epinastine (monohydrochloride) 108929-04-0 C16H16ClN3 285.77

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Epinastine

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