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58581-89-8 (Azelastine)

1

Identification

Azelastine Azelastine
Name Azelastine
Formula C22H24ClN3O
MW 381.9
CAS No. 58581-89-8
EINECS
Smiles O=C1N(C2CCN(C)CCC2)N=C(CC3=CC=C(Cl)C=C3)C4=C1C=CC=C4
Synonyms Astelin;Optivar;Allergodil;Rhinolast;Optilas; 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one
InChI InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3
2

Introduction

Azelastine is a potent, second-generation, selective, histamine antagonist. Target: Histamine Receptor Azelastine is a selective H(1)-receptor antagonist that inhibits histamine release and interferes with activation of several other mediators of allergic inflammation.

Background Information

Azelastine, a phthalazine derivative, is a potent, second-generation, selective, histamine antagonist used as a first line therapy of mild intermittent. ......by BOC Sciences
Azelastine HCl is a potent, second-generation, selective, histamine antagonist. ......by Target Molecule Corp.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance: EBNumber:EB000011799

Storage condition

Solubility

DMSO by MedChemexpress Co., Ltd.
5

Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Azelastine - Launched
7

Safety Data of Azelastine

8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD60();200mg/USD82() USA
Lemman Laboratories International Co., Ltd. China
MedChemexpress Co., Ltd. 100mg/USD60();200mg/USD82() USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();200mg/USD82() China
Shanghai RenYoung Pharmaceutical Co., Ltd. China
Shenyang Funing Pharmaceuticals Co., Ltd. China
Suzhou Huihe Pharm Co., Ltd. China
Target Molecule Corp. 10mg/USD20();50mg/USD75();100mg/USD132() USA
Zhuhai Sanxin Fine Chemical Co., Ltd. China
10

Related Products

Other Forms of 58581-89-8

Name CAS No Formula MW
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Doxylamine (succinate) 562-10-7 C21H28N2O5 388.46
Ebastine 90729-43-4 C32H39NO2 469.66
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

Azelastine

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