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4373-41-5 (Maslinic acid)

1

Identification

Maslinic acid Maslinic acid
Name Maslinic acid
Formula C30H48O4
MW 472.7
CAS No. 4373-41-5
EINECS
Smiles C[[email protected]]12[[email protected]@](CC[[email protected]](CC3)(C(O)=O)[[email protected]@]4([H])CC3(C)C)(C)C4=CC[[email protected]]1([H])[[email protected]](C[[email protected]]5O)(C)[[email protected]@](C(C)(C)[[email protected]]5O)([H])CC2
Synonyms (2alpha,3beta)-2,3-Dihydroxy-olean-12-en-28-oic acid; (4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid
InChI InChI=1S/C30H48O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)16-25)8-9-22-27(5)17-20(31)23(32)26(3,4)21(27)10-11-29(22,28)7/h8,19-23,31-32H,9-17H2,1-7H3,(H,33,34)/t19-,20+,21-,22+,23-,27-,28+,29+,30-/m0/s1
2

Introduction

Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation

Background Information

Maslinic Acid is a pentacyclic triterpene with antioxidant and anti-inflammatory properties. Studies indicate that Maslinic Acid blocks the generation of nitric oxide, and inhibits the secretion of IL-6 and TNF-?? induced by lipopolysaccharides. Maslinic Acid is described to have antiproliferative and anti-HIV properties. ......by AdooQ BioScience, LLC
Maslinic acid is a pentacyclic triterpene found in a variety of natural sources. It exerts a wide range of biological activities, such as antitumor, antidiabetic, antioxidant, cardioprotective, neuroprotective, antiparasitic and growth-stimulating. ......by BOC Sciences
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation ......by MedChemexpress Co., Ltd.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011615

Storage condition

4°C by MedChemexpress Co., Ltd.

Solubility

1 mg/mL in acetone by CHEMSCENE, LLC
1 mg/mL in acetone by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways NF-κB Immunology/Inflammation
Target COX NF-κB
Research Area Cancer
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Maslinic acid - No Development Reported
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Safety Data of Maslinic acid

8

Spectral Information

9

Suppliers List

10

Related Products

Other Forms of 4373-41-5

Name CAS No Formula MW

Recommended Compounds in COX NF-κB

Name CAS No Formula MW
Isoorientin 4261-42-1 C21H20O11 448.3769
Aceclofenac 89796-99-6 C16H13Cl2NO4 354.18
Zaltoprofen 74711-43-6 C17H14O3S 298.36
Ketorolac 74103-06-3 C15H13NO3 255.27
Loxoprofen 68767-14-6 C15H18O3 246.3
Mefenamic acid 61-68-7 C15H15NO2 241.29
Nabumetone 42924-53-8 C15H16O2 228.29
Triflusal 322-79-2 C10H7F3O4 248.16
Diclofenac (diethylamine) 78213-16-8 C18H22Cl2N2O2 369.29
Bufexamac 2438-72-4 C12H17NO3 223.27
Acemetacin 53164-05-9 C21H18ClNO6 415.82
Phenacetin 62-44-2 C10H13NO2 179.22
Tenoxicam 59804-37-4 C13H11N3O4S2 337.37
Flunixin (meglumine) 42461-84-7 0.0
Lornoxicam 70374-39-9 C13H10ClN3O4S2 371.82
Nimesulide 51803-78-2 C13H12N2O5S 308.31
Tolfenamic Acid 13710-19-5 C14H12ClNO2 261.7
Fenoprofen (Calcium) 34597-40-5 C30H26CaO6 522.6
Deracoxib 169590-41-4 C17H14F3N3O3S 397.37
Meloxicam 71125-38-7 C14H13N3O4S2 351.4

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

13

More Information

Maslinic acid

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