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54-71-7 (Pilocarpine (Hydrochloride))

1

Identification

Pilocarpine (Hydrochloride) Pilocarpine (Hydrochloride)
Name Pilocarpine (Hydrochloride)
Formula C11H17ClN2O2
MW 244.72
CAS No. 54-71-7
EINECS 200-212-5
Smiles O=C1[[email protected]@H](CC)[[email protected]](CO1)CC2=CN=CN2C.Cl
Synonyms (3S,4R)-4,5-Dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride; (3S,4R)-3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one hydrochloride
InChI InChI=1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
2

Introduction

Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. Target: mAChR Pilocarpine is a parasympathomimetic alkaloid obtained from the leaves of tropical American shrubs from the genus Pilocarpus.

Background Information

Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. ......by BOC Sciences
Pilocarpine Hydrochloride is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. ......by MedChemexpress Co., Ltd.
Pilocarpine hydrochloride is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Systemic administration of (+)-pilocarpine is typically used as an animal model for temporal lobe epilepsy and can mimic the generation of complex partial seizures by producing changes in hippocampal neuron morphology, membrane properties, and synaptic responses. Pilocarpine is used as a miotic and in the treatment of glaucoma. ......by MedKoo Biosciences, Inc.
Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. ......by Selleck Chemicals LLC
Pilocarpine HCl is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy. ......by Target Molecule Corp.
Muscarinic agonist. ......by Tocris Bioscience Inc.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000011601

Storage condition

Desiccate at RT by Tocris Bioscience Inc.

Solubility

DMSO 49 mg/mL; Water 49 mg/mL by MedChemexpress Co., Ltd.
Soluble to 75 mM in DMSO and to 100 mM in water by Tocris Bioscience Inc.
5

Mechanism and Indication

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Pilocarpine (Hydrochloride) - Launched
7

Safety Data of Pilocarpine (Hydrochloride)

´╗┐Hazard Symbols : T+
´╗┐Risk Statements : R26/28
Safety Statements : S25;S45
Transport Information : UN 1544
RTECS : TK1450000
WGKGermany : 3
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Alfa Chemistry USA
BOC Sciences
Biochempartner Co., Ltd China
Boehringer Ingelheim GmbH Germany
CHEMSCENE, LLC 100mg/USD60();500mg/USD96() USA
Cayman Chemical Company USA
Chengdu Biopurify Phytochemicals Ltd. China
MedChemexpress Co., Ltd. 100mg/USD60();500mg/USD96() USA
MedKoo Biosciences, Inc. USA
Molekula Ltd
Selleck Chemicals LLC USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD60();500mg/USD96() China
Target Molecule Corp. 2mg/USD20();10mg/USD46();50mg/USD101();200mg/USD122() USA
Tocris Bioscience Inc. USA
10

Related Products

Other Forms of 54-71-7

Name CAS No Formula MW
Pilocarpine 92-13-7 C11H16N2O2 208.26
Pilocarpine (nitrate) 148-72-1 C11H17N3O5 271.26978

Recommended Compounds in mAChR

Name CAS No Formula MW
Imidafenacin 170105-16-5 C20H21N3O 319.4
Flavoxate (hydrochloride) 3717-88-2 C24H26ClNO4 427.92
Homatropine (Bromide) 51-56-9 C16H22BrNO3 356.25
Benztropine (mesylate) 132-17-2 C22H29NO4S 403.54
Otilonium (bromide) 26095-59-0 C29H43BrN2O4 563.57
Arecoline (hydrobromide) 300-08-3 C8H14BrNO2 236.11
Trospium (chloride) 10405-02-4 C25H30ClNO3 427.96
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 490.43
Revefenacin 864750-70-9 C35H43N5O4 597.747
Oxybutynin (chloride) 1508-65-2 C22H32ClNO3 393.95
Gallamine Triethiodide 65-29-2 C30H60I3N3O3 891.53
Bethanechol (chloride) 590-63-6 C7H17ClN2O2 196.68
Atropine (sulfate monohydrate) 5908-99-6 C34H50N2O11S 694.83
Methscopolamine (bromide) 155-41-9 C18H24BrNO4 398.29
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 372.16
Irsogladine 57381-26-7 C9H7Cl2N5 256.09
Tropicamide 1508-75-4 C17H20N2O2 284.35
Oxybutynin 5633-20-5 C22H31NO3 357.49
Ipratropium (bromide) 22254-24-6 C20H30BrNO3 412.36
Scopolamine (hydrobromide) 114-49-8 C17H22BrNO4 384.26

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

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More Information

Pilocarpine (Hydrochloride)

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