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59-42-7 (L-Phenylephedrine)

1

Identification

L-Phenylephedrine L-Phenylephedrine
Name L-Phenylephedrine
Formula C9H13NO2
MW 167.21
CAS No. 59-42-7
EINECS 200-424-8
Smiles O[[email protected]@H](CNC)C1=CC(O)=CC=C1
Synonyms 3-Hydroxy-alpha-((methylamino)methyl)-benzyl alcohol; (R)-3-(1-hydroxy-2-(methylamino)ethyl)phenol
InChI InChI=1S/C9H13NO2/c1-10-6-9(12)7-3-2-4-8(11)5-7/h2-5,9-12H,6H2,1H3/t9-/m0/s1
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Introduction

Background Information

(R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant. InVitro: (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist with pKi values of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively[1][2]. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis[3]. InVivo: Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes[4]. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema[5]. ......by MedChemexpress Co., Ltd.
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Protocol(Only for Reference)

Cell Experiment

Animal Experiment

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Physical and Chemical Properties

Appearance: EBNumber:EB000011535

Storage condition

Solubility

DMSO by CHEMSCENE, LLC
in DMSO by MedChemexpress Co., Ltd.
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Mechanism and Indication

Signaling Pathways GPCR/G Protein
Target Adrenergic Receptor
Research Area Metabolic Disease
Indications
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Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
L-Phenylephedrine Bayer 2009/9/11 2015/2/20 Phase 3
L-Phenylephedrine - Phase 3 Clinical
L-Phenylephedrine - Launched
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Safety Data of L-Phenylephedrine

Hazard Symbols : Xn
Risk Statements : 22-36/37/38-41-37/38
Safety Statements : 26-36-45-39
RTECS : DO7175000
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Spectral Information

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Suppliers List

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Related Products

Other Forms of 59-42-7

Name CAS No Formula MW
(R)-(-)-Phenylephrine (hydrochloride) 61-76-7 C9H14ClNO2 203.67

Recommended Compounds in Adrenergic Receptor

Name CAS No Formula MW
Tolazoline 59-98-3 C10H12N2 160.22
Synephrine (hydrochloride) 5985-28-4 C9H14ClNO2 203.67
Nicergoline 27848-84-6 C24H26BrN3O3 484.39
Tamsulosin (hydrochloride) 106463-17-6 C20H29ClN2O5S 444.97
Tamsulosin 106133-20-4 C20H28N2O5S 408.51
UK 14,304 59803-98-4 C11H10BrN5 292.13
Guanfacine 29110-47-2 C9H9Cl2N3O 246.09
Propranolol (hydrochloride) 318-98-9 C16H22ClNO2 295.8
Guanabenz (Acetate) 23256-50-0 C10H12Cl2N4O2 291.13
Tetrahydrozoline (hydrochloride) 522-48-5 C13H17ClN2 236.74
Octopamine (hydrochloride) 770-05-8 C8H12ClNO2 189.64
Betaxolol (hydrochloride) 63659-19-8 C18H30ClNO3 343.89
Indacaterol (maleate) 753498-25-8 C28H32N2O7 508.56
Medetomidine (hydrochloride) 86347-15-1 C13H17ClN2 236.74
Norepinephrine (bitartrate monohydrate) 108341-18-0 C12H19NO10 337.28
Norepinephrine (hydrochloride) 329-56-6 C8H12ClNO3 205.64
Xylometazoline (hydrochloride) 1218-35-5 C16H25ClN2 280.84
(R)-(-)-Phenylephrine (hydrochloride) 61-76-7 C9H14ClNO2 203.67
Isoprenaline (hydrochloride) 51-30-9 C11H18ClNO3 247.72
Scopine 498-45-3 C8H13NO2 155.19

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

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References

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More Information

L-Phenylephedrine

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