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562-10-7 (Doxylamine (succinate))

1

Identification

Doxylamine (succinate) Doxylamine (succinate)
Name Doxylamine (succinate)
Formula C21H28N2O5
MW 388.46
CAS No. 562-10-7
EINECS 209-228-7
Smiles CC(C1=NC=CC=C1)(OCCN(C)C)C2=CC=CC=C2.OC(CCC(O)=O)=O
Synonyms N,N-Dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine succinate; N,N-dimethyl-2-(1-phenyl-1-(pyridin-2-yl)ethoxy)ethanamine succinate
InChI InChI=1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
2

Introduction

Doxylamine is a first generation antihistamine; can be used by itself as a short-term sedative and in combination with other drugs to provide night-time allergy and cold relief.

Background Information

Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects. ......by BOC Sciences
Doxylamine Succinate is a pyridine histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes. ......by MedKoo Biosciences, Inc.
Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects. ......by Selleck Chemicals LLC
Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects. ......by Target Molecule Corp.
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white Solid EBNumber:EB000010099

Storage condition

Solubility

5

Mechanism and Indication

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology
Indications
6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Doxylamine (succinate) - Launched
7

Safety Data of Doxylamine (succinate)

´╗┐Hazard Symbols : Xn
´╗┐Risk Statements : R22;R36/37/38
Safety Statements : S26;S36/37
RTECS : US9275000
WGKGermany : 2
8

Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
AA Blocks LLC
Aladdin 5g/RMB729();10g/RMB1299();50g/RMB3999() China
BOC Sciences
Biochempartner Co., Ltd China
CHEMSCENE, LLC 100mg/USD72() USA
Cayman Chemical Company USA
Ceres Chemical Co. Inc. USA
MedChemexpress Co., Ltd. 100mg/USD72() USA
MedKoo Biosciences, Inc. USA
Santa Cruz Biotechnology, Inc. 100mg/USD220() USA
Selleck Chemicals LLC 50mg/USD122(In stock) USA
Shanghai Haoyuan Chemexpress Co., Ltd. 100mg/USD72() China
Sigma-Aldrich, Inc. 5g/USD66() USA
Spectrum Chemical Mfg. Corp. 5g/USD93() USA
Target Molecule Corp. 2mg/USD20();5mg/USD40();10mg/USD65();50mg/USD195();100mg/USD325() USA
Zhuhai Hairuide Bioscience And Technology Co., Ltd. China
10

Related Products

Other Forms of 562-10-7

Name CAS No Formula MW
Doxylamine 469-21-6 C17H22N2O 270.37
Doxylamine (D5 succinate) 1216840-94-6 C21H23D5N2O5 393.49
Doxylamine (D5) 1173020-59-1 C17H17D5N2O 275.4

Recommended Compounds in Histamine Receptor

Name CAS No Formula MW
Ebastine 90729-43-4 C32H39NO2 469.66
Azelastine 58581-89-8 C22H24ClN3O 381.9
Epinastine 80012-43-7 C16H15N3 249.31
Hydroxyzine (dihydrochloride) 2192-20-3 C21H29Cl3N2O2 447.83
Hydroxyzine 68-88-2 C21H27ClN2O2 374.9
Desloratadine 100643-71-8 C19H19ClN2 310.82
Pemirolast (potassium) 100299-08-9 C10H7KN6O 266.3
Betahistine (dihydrochloride) 5579-84-0 C8H14Cl2N2 209.12
Brompheniramine (maleate) 980-71-2 C20H23BrN2O4 435.31
Azelastine (hydrochloride) 79307-93-0 C22H25Cl2N3O 418.36
Olopatadine (hydrochloride) 140462-76-6 C21H24ClNO3 373.87
Famotidine 76824-35-6 C8H15N7O2S3 337.45
Meclizine (dihydrochloride) 1104-22-9 C25H29Cl3N2 463.87
Nizatidine 76963-41-2 C12H21N5O2S2 331.46
Roxatidine (Acetate Hydrochloride) 93793-83-0 C19H29ClN2O4 384.9
Diphenhydramine (hydrochloride) 147-24-0 C17H22ClNO 291.82
Clemastine (fumarate) 14976-57-9 C25H30ClNO5 459.96
Chlorpheniramine (maleate) 113-92-8 C20H23ClN2O4 390.86
Ranitidine (hydrochloride) 66357-59-3 C13H23ClN4O3S 350.86
Mianserin (hydrochloride) 21535-47-7 C18H21ClN2 300.83

Recommended Compounds in Same Indication

Name CAS No Formula MW
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Route of Synthesis

12

References

[1]. Doxylamine, From Wikipedia

Protocol Reference

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More Information

Doxylamine (succinate)

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