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173441-26-4 (MMAD (hydrochloride))

1

Identification

MMAD (hydrochloride) MMAD (hydrochloride)
Name MMAD (hydrochloride)
Formula C41H67ClN6O6S
MW 807.5253
CAS No. 173441-26-4
EINECS
Smiles O=C([[email protected]](C)[[email protected]]([[email protected]]1([H])CCCN1C(C[[email protected]@H](OC)[[email protected]]([[email protected]@H](C)CC)N(C([[email protected]@H](NC([[email protected]@H](N(C)[H])C(C)C)=O)C(C)C)=O)C)=O)OC)N[[email protected]@H](CC2=CC=CC=C2)C3=NC=CS3.Cl
Synonyms Demethyldolastatin 10 hydrochloride;Monomethylauristatin D hydrochloride;Monomethyl Dolastatin 10 hydrochloride
InChI InChI=1S/C41H66N6O6S.ClH/c1-12-27(6)36(46(9)41(51)35(26(4)5)45-39(50)34(42-8)25(2)3)32(52-10)24-33(48)47-21-16-19-31(47)37(53-11)28(7)38(49)44-30(40-43-20-22-54-40)23-29-17-14-13-15-18-29;/h13-15,17-18,20,22,25-28,30-32,34-37,42H,12,16,19,21,23-24H2,1-11H3,(H,44,49)(H,45,50);1H/t27-,28+,30-,31-,32+,34-,35-,36-,37+;/m0./s1
2

Introduction

A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs).

Background Information

For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately ......by BOC Sciences
A potent tubulin inhibitor that is a toxin payload in antibody drug conjugates (ADCs). ......by ProbeChem
3

Protocol(Only for Reference)

Cell Experiment

Animal Experiment

4

Physical and Chemical Properties

Appearance:White to off-white solid EBNumber:EB000010016

Storage condition

Solubility

5

Mechanism and Indication

6

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
MMAD (hydrochloride) - Not Found
MMAD (hydrochloride) - No Development Reported
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Safety Data of MMAD (hydrochloride)

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Spectral Information

9

Suppliers List

Company Price and Availability Country/Region
Apexbio Technology LLC USA
Ark Pharm, Inc. USA
BOC Sciences
Biochempartner Co., Ltd China
ProbeChem
10

Related Products

Other Forms of 173441-26-4

Name CAS No Formula MW

Recommended Compounds in Microtubule/Tubulin ADC Cytotoxin

Name CAS No Formula MW
7-Epi-docetaxel 153381-68-1 C43H53NO14 807.88
7-Epi-10-oxo-docetaxel 162784-72-7 C43H51NO14 805.86
10-Oxo Docetaxel 167074-97-7 C43H51NO14 805.86
MMAF (Hydrochloride) 1415246-68-2 C39H66ClN5O8 768.42
Tubulysin A 205304-86-5 C43H65N5O10S 844.07
Vinflunine 162652-95-1 C45H54F2N4O8 816.93
Triclabendazole 68786-66-3 C14H9Cl3N2OS 359.66
Eribulin mesylate 441045-17-6 C41H63NO14S 826.0
Vincristine (sulfate) 2068-78-2 C46H58N4O14S 923.04
Vc-MMAD 1401963-17-4 C70H104N12O14S 1369.71
Mc-MMAE 863971-24-8 C49H78N6O10 911.18
Mc-MMAD 1401963-15-2 C51H77N7O9S 964.26
Vinorelbine (ditartrate) 125317-39-7 C53H66N4O20 1079.11
Fosbretabulin (disodium) 168555-66-6 C18H19Na2O8P 440.29
4'-Demethylepipodophyllotoxin 6559-91-7 C21H20O8 400.38
Vinblastine 865-21-4 C46H58N4O9 810.97
Vinblastine (sulfate) 143-67-9 C46H60N4O13S 909.05
Tasidotin hydrochloride 623174-20-9 C32H59ClN6O5 643.3
Taltobulin 228266-40-8 C27H43N3O4 473.64802
Auristatin F 163768-50-1 C40H67N5O8 745.99

Recommended Compounds in Same Indication

Name CAS No Formula MW
11

Route of Synthesis

12

References

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More Information

MMAD (hydrochloride)

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