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AbMole BioScience

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Basic Information

Company Name:AbMole BioScience

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Country/Region:USA

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Year Established:

Introduction of AbMole BioScience

AbMole BioScience is a rapidly growing, professional inhibitors supplier. We provide high purity life science reagents such as kinase inhibitors for laboratory research. We have unique collection of over 3000 inhibitors on HDAC, PI3K, Apoptosis and more signaling pathways in stock.

Web: www.abmole.com TEL:1-800-660-8580 Fax: Email:[email protected]

Products of AbMole BioScience

  • Chemical Name: IM-12
    CAS No.: 1129669-05-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: IM 12;IM12; 3-((4-fluorophe... Quality Control & MSDS Files:
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    Brief introduction:

    IM-12 is a potent and selective GSK-3β inhibitor with IC50 of 53 nM, which also enhances canonical Wnt signalling. IM-12 inhibits GSK-3β activity with IC50 of 3.8 μM and subsequently increases β-catenin concentration significantly in hNPCs. IM-12 significantly increased β-catenin levels. When used to treat human neural progenitor cells...

  • Chemical Name: Nexturastat A
    CAS No.: 1403783-31-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-((1-butyl-3-phenylureido)... Quality Control & MSDS Files:
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    Brief introduction:

    Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM, >190-fold selectivity over other HDACs.

  • Chemical Name: 4SC-202
    CAS No.: 910462-43-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4SC 202 free base;4SC202 fr... Quality Control & MSDS Files:
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    Brief introduction:

    4SC-202 induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres. In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM.

  • Chemical Name: Defactinib
    CAS No.: 1073154-85-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VS-6063;VS6063;VS 6063; N-m... Quality Control & MSDS Files:
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    Brief introduction:

    The combination of VS-6063 and paclitaxel synergistically decreases proliferation and increases apoptosis in SKOV3ip1, SKOV3-TR, HeyA8 and HeyA8-MDR cells. In both PTX-sensitive and PTX-resistant models, VS-6063 (50 mg/kg p.o.) enhances tumor growth inhibition by paclitaxel.

  • Chemical Name: Serabelisib
    CAS No.: 1268454-23-4 Purity: Appearances: White to gray Solid
    Brand: Synonyms: Serabelisib;INK1117 Quality Control & MSDS Files:
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    Brief introduction:

    In vitro: TAK-117 administration in PIK3CA-mutant tumor cell lines results in potent PI3K pathway inhibition, blockade of cellular proliferation, and apoptosis. INK1117 potently inhibits PI3K and demonstrates a greater than 100-fold selectivity relative to other class I PI3K family members and mTOR as well as a high degree of selectivi...

  • Chemical Name: Rostafuroxin
    CAS No.: 156722-18-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PST-2238;PST 2238;PST2238; ... Quality Control & MSDS Files:
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    Brief introduction:

    Rostafuroxin (PST 2238) is a new oral antihypertensive agent able to selectively antagonize EO, adducin pressor, and molecular effects. It is endowed with high potency and efficacy in reducing blood pressure and preventing organ hypertrophy in animal models representative of both adducin and EO mechanisms.At molecular level, in the kid...

  • Chemical Name: Saxagliptin hydrate
    CAS No.: 945667-22-1 Purity: Appearances:
    Brand: Synonyms: BMS-477118 hydrate;Onglyza ... Quality Control & MSDS Files:
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    Brief introduction:

    Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

  • Chemical Name: GNE-9605
    CAS No.: 1536200-31-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: GNE 9605;GNE9605;N2-(5-chlo... Quality Control & MSDS Files:
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    Brief introduction:

    GNE-9605 is a highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. Leucine-rich repeat kinase 2 (LRRK2) has drawn significant interest in the neuroscience research community because it is one of the most compelling targets for a potential disease-modifying Parkinson...

  • Chemical Name: Pirarubicin HCl
    CAS No.: 95343-20-7 Purity: Appearances: Pink to red Solid
    Brand: Synonyms: THP Hydrochloride; (8S,10S)... Quality Control & MSDS Files:
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    Pirarubicin Hcl is an analogue of the anthracycline anti-neoplastic doxorubicin, which is an inhibitor of Topo II.

  • Chemical Name: TGR-1202
    CAS No.: 1532533-67-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: TGR 1202;TGR1202; (S)-2-(1-... Quality Control & MSDS Files:
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    In vitro: The compound displays a high degree of selectivity over the alpha (>1000 fold), beta (>30-50 fold), and gamma (>15-50 fold) isoforms. Additionally, the compound causes a half-maximal inhibition of human whole blood CD19 cell proliferation between 100-300 nM. Treatment of PBMC with RP5264 results initially in a G2/M a...

  • Chemical Name: K02288
    CAS No.: 1431985-92-0 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: K-02288; K 02288; K 02288. Quality Control & MSDS Files:
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    Brief introduction:

    K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.

  • Chemical Name: MI-2
    CAS No.: 1047953-91-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: MALT1 inhibitor Quality Control & MSDS Files:
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    MI-2 binds directly to MALT1 and irreversibly suppresses protease function. MI-2 decreases NF-κB activity induced by MALT1. MI-2 inhibits cell proliferation and MALT1-mediated cleavage activity. MI-2 concentrates within human ABC-DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates. MI-2 displayes selective activity agai...

  • Chemical Name: FR 180204
    CAS No.: 865362-74-9 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: FR 180204;FR-180204; 5-(2-p... Quality Control & MSDS Files:
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    Brief introduction:

    FR180204 inhibited the kinase activity of ERK1 and ERK2, with K(i) values 0.31 and 0.14microM, respectively. FR180204 inhibited TGFbeta-induced luciferase-expression. FR180204 inhibited in vitro CII-induced proliferation of lymph node cells prepared from CII-immunized mice, in which CII-specific T cells are known to undergo specific pr...

  • Chemical Name: ML347
    CAS No.: 1062368-49-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: ML 347;ML-347;LDN-193719;LD... Quality Control & MSDS Files:
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    Brief introduction:

    ML347 is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM.

  • Chemical Name: PSN632408
    CAS No.: 857652-30-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PSN 632408;PSN-632408; tert... Quality Control & MSDS Files:
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    Brief introduction:

    PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 µM, respectively (EC50 values for OEA are 3.2 and 2.9 µM, respectively). PSN632408 has been reported to activate human and mouse GPR119 in a yeast fluorimetr...

  • Chemical Name: CFTRinh-172
    CAS No.: 307510-92-5 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: CFTR Inhibitor-172;CFTRinh-... Quality Control & MSDS Files:
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    Brief introduction:

    CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with K<sub>i</sub> of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters.

  • Chemical Name: Oncrasin-1
    CAS No.: 75629-57-1 Purity: Appearances: Light yellow to earth yellow Solid
    Brand: Synonyms: Oncrasin 1;Oncrasin1; 1-(4-... Quality Control & MSDS Files:
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    Brief introduction:

    Oncrasin-1 is a proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Oncrasin-...

  • Chemical Name: CB-839
    CAS No.: 1439399-58-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 2-(pyridin-2-yl)-N-(5-(4-(6... Quality Control & MSDS Files:
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    Brief introduction:

    In vitro: CB-839 exhibits time-dependent and slowly reversible kinetics. IC50 values for glutaminase inhibition by CB-839 following preincubation with rHu-GAC for-1 hour are &lt; 50 nmol/L, at least 13-fold lower than with BPTES. CB-839 has antiproliferative activity in a triple-negative breast cancer (TNBC) cell line, HCC-1806, while ...

  • Chemical Name: Z-VAD(OMe)-FMK
    CAS No.: 187389-52-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Z-Val-Ala-Asp(OMe)-FMK Quality Control & MSDS Files:
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    Brief introduction:

    Z-VAD(OMe)-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells.Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK ...

  • Chemical Name: Eluxadoline
    CAS No.: 864821-90-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: JNJ 27018966;JNJ27018966;JN... Quality Control & MSDS Files:
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    Brief introduction:

    Coadministration of a single 200?mg dose of eluxadoline with cyclosporine, and probenecid increased eluxadoline systemic exposure [AUC(0-inf) ] by 4.4- and 1.4-fold, respectively, whereas peak exposure (Cmax ) increased 6.2-fold and 1.3-fold, respectively. Cyclosporine had little effect on renal clearance (CLren ) of eluxadoline wherea...