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MedKoo Biosciences, Inc.

23758

Basic Information

Company Name:MedKoo Biosciences, Inc.

Business Type:Chemical distributor

Total NO.Employees:

Country/Region:USA

Certificates:

Year Established:

Introduction of MedKoo Biosciences, Inc.

MedKoo is a world leading provider of small molecule anticancer reagents, kinase inhibitors and other pharmaceutical related chemicals. We have operation office located in Research Triangle Park, North Carolina, USA, and have research and manufacturing facilities in China. MedKoo was founded in 2009 by Dr. Qingqi Chen, who obtained a Ph.D. in synthetic/medicinal chemistry from Peking University, and received postdoctoral trainings at Johannes-Kepler University Linz (with Dr. Heinz Falk), University of Nevada Reno (with Dr. David Lightner), and University of British Columbia (with Dr. David Dolphin). Dr. Chen is currently the President and CEO of MedKoo. Prior to joining MedKoo, Dr. Chen was a distinguished professor at the School of Pharmaceutical Sciences of Zhongshan University (Sun Yat-sen University, Guangzhou, China) and a "100-person-plan" professor at the Chinese Academy of Sciences (Beijing, China). Dr. Chen also held senior positions in several pharmaceutical companies in USA, where he made contributions to the R&D of several FDA approved drugs. Dr. Chen has a strong interest in small molecule anticancer drug discovery and has published over 100 papers, submitted 20 patent applications, and authorized or co-authorized 8 books, including "Anticancer Small Molecular Libraries"; "New Drugs in Development for Cancers"; " A Fast Guide to Anti-Cancer Drug Substances, Drug Products and Their Total Synthetic Routes". (all books were written in Chinese, published by Science Press, Beijing). Our team includes most qualified and talented synthetic and medicinal chemists and pharmaceutical marketing experts. They have the experience to manage the complex activities and tight time lines required for pharmaceutical projects. MedKoo is capable to provide qualified products and services at a very competitive price. Medkoo offers products and service from discovery and early medicinal chemistry to multiple kilogram scale synthesis Our success is due to our competitive pricing, our firmly commitment to customer service and to the talent and experience of our scientists, most of whom hold doctorates in chemistry, pharmaceuticals and chemical engineers. Our services include: Research services: including all areas of medicinal chemistry research, custom organic synthesis, synthetic route optimization, synthetic process development, formulation development, bioanalytical services, molecule sourcing services, and molecule distributing services. About the name "MedKoo" MedKoo was originated from the combination of two words: "Medicine" and "Koo". In Chinese, "Koo" means big stockroom or warehouse. MedKoo literally means a comprehensive collection of medicinal chemicals.

Web: www.medkoo.com TEL:919-279-0682 Fax:919-980-4831 Email:[email protected]

Products of MedKoo Biosciences, Inc.

  • Chemical Name: AMG-837 calcium hydrate
    CAS No.: 1259389-38-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AMG-837 calcium hydrate;AMG... Quality Control & MSDS Files:
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    AMG-837 is a potent, orally bioavailable GPR40 agonist. AMG 837 was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Acute administration of AMG 837 lowered glucose excursions and increased glucose stimulated insulin secretion during gluc...

  • Chemical Name: PEAQX sodium
    CAS No.: 459836-30-7 Purity: Appearances:
    Brand: Synonyms: NVP-AAM077 Quality Control & MSDS Files:
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    PEAQX, also known as NVP-AAM077; is a competitive antagonist at the NMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies of the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is ...

  • Chemical Name: LY2857785
    CAS No.: 1619903-54-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: LY 2857785;LY-2857785; (1r,... Quality Control & MSDS Files:
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    LY2857785 is a potent CDK9 inhibitor with potential anticancer activity. LY2857785 significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines. LY2857785 inhibits the growth of a broad panel of cancer cell lines, and is parti...

  • Chemical Name: Etomoxir sodium salt
    CAS No.: 828934-41-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (+)-Etomoxir sodium salt; s... Quality Control & MSDS Files:
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    Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essentia...

  • Chemical Name: IM-12
    CAS No.: 1129669-05-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: IM 12;IM12; 3-((4-fluorophe... Quality Control & MSDS Files:
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    IM-12 is a cell-permeable indolylmaleimide that acts as a GSK-3β inhibitor. IM-12 is potent and selective enhances canonical Wnt signalling. IM-12 inhibits GSK-3β activity and subsequently increases β-catenin concentration significantly in hNPCs. When used to treat human neural progenitor cells, IM-12 promoted neuronal differentiation ...

  • Chemical Name: Nexturastat A
    CAS No.: 1403783-31-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: 4-((1-butyl-3-phenylureido)... Quality Control & MSDS Files:
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    Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM). Nexturastat A possesses antiproliferative effects against melanoma cells. Histone deacetylases (HDACs) mediate regulation of gene expression via changes in nucleosome conformation. Dys...

  • Chemical Name: Kb-NB77-78
    CAS No.: 1350622-33-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: 9-((tert-butyldimethylsilyl... Quality Control & MSDS Files:
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    Kb-NB77-78 is a CID-797718 analog that may bind PKD1

  • Chemical Name: KB-NB77-78
    CAS No.: 350622-33-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: 9-((tert-butyldimethylsilyl... Quality Control & MSDS Files:
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    KB-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673 (PKD1 inhibitor).

  • Chemical Name: HG-6-64-1
    CAS No.: 1315329-43-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: HG-6-64-1;HG 6-64-1; (E)-N-... Quality Control & MSDS Files:
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    HG-6-64-1 is a selective B-Raf and mutant B-Raf inhibitor.

  • Chemical Name: Defactinib free base
    CAS No.: 1073154-85-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: VS-6063;VS6063;VS 6063; N-m... Quality Control & MSDS Files:
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    Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, i...

  • Chemical Name: Ozanimod
    CAS No.: 1306760-87-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: RPC-1063 Quality Control & MSDS Files:
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    Ozanimod, also known as RPC1063, is a selective sphingosine 1 phosphate receptor modulators and methods which may be useful in the treatment of S1P1-​associated diseases.

  • Chemical Name: YH239-EE
    CAS No.: 1364488-67-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: YH 239-EE;YH 239 EE; ethyl ... Quality Control & MSDS Files:
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    YH239-EE is a highly potent p53-MDM2 antagonist.

  • Chemical Name: Uracil
    CAS No.: 66-22-8 Purity: Appearances:
    Brand: Synonyms: 2,4(1H,3H)-Pyrimidinedione;... Quality Control & MSDS Files:
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    Uracil is one of the four nucleobases in the nucleic acid of RNA that are represented by the letters A, G, C and U. The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine. Uracil is a demethylated form of thymine. Uracil's u...

  • Chemical Name: MLN-1117
    CAS No.: 1268454-23-4 Purity: Appearances: White to gray Solid
    Brand: Synonyms: Serabelisib;INK1117 Quality Control & MSDS Files:
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    Serabelisib (also known as MLN1117, INK1117, and TAK-117) is an orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha isoform with potential antineoplastic activity. PI3K alpha inhibitor INK1117 selectively inhibits PI3K alpha kinase, including mutations of PIK3CA, in the PI3K/Akt/mTOR pathway, which may r...

  • Chemical Name: NVP-QAV-680
    CAS No.: 872365-16-7 Purity: Appearances:
    Brand: Synonyms: NVP-QAV-680 Quality Control & MSDS Files:
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    NVP-QAV-680 is a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. A highly selective compound, it has low nM functional potency for inhibition of CRTh2 driven human eosinophil and Th2 lymphocyte activation in vitro.

  • Chemical Name: Liothyronine sodium
    CAS No.: 55-06-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: T3 Sodium salt;Sodium L-3,3... Quality Control & MSDS Files:
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    Liothyronine sodium is a metabolite of THYROXINE, formed by the peripheral enzymatic monodeiodination of T4 at the 5 position of the inner ring of the iodothyronine nucleus. It is also a T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peri...

  • Chemical Name: Liothyronine Sodium
    CAS No.: 6893-02-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: T3 Sodium salt;Sodium L-3,3... Quality Control & MSDS Files:
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    Liothyronine is a synthetic form of thyroid hormone (T3) used to treat hypothyroidism and myxedema coma. It is also used as an augmentation strategy in treating Major Depressive Disorder when used in combination with antidepressants. It is marketed as the sodium salt under the brand name Cytomel (or Tertroxin in Australia).

  • Chemical Name: Rostafuroxin
    CAS No.: 156722-18-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PST-2238;PST 2238;PST2238; ... Quality Control & MSDS Files:
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    Rostafuroxin, also known as PST-2238, is an ouabain antagonist. Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain. Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+...

  • Chemical Name: Saxagliptin hydrate
    CAS No.: 945667-22-1 Purity: Appearances:
    Brand: Synonyms: BMS-477118 hydrate;Onglyza ... Quality Control & MSDS Files:
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    Brief introduction:

    Saxagliptin, also known as BMS-477118, is a new oral hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Saxagliptin was approved in 2008 for the treatment of type 2 diabetes. Saxagliptin is a competitive DPP4 inhibitor that slows the inactivation of the incretin hormones, thereby incre...

  • Chemical Name: Fidaxomicin
    CAS No.: 873857-62-6 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: OPT-80;PAR-101;Dificid;Difi... Quality Control & MSDS Files:
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    Brief introduction:

    Fidaxomicin is the first in a new class of narrow spectrum macrocyclic antibiotic drugs. It is a fermentation product obtained from the actinomycete Dactylosporangium aurantiacum subspecies hamdenesis. Fidaxomicin is non-systemic, meaning it is minimally absorbed into the bloodstream, it is bactericidal, and it has demonstrated selecti...