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MedChemexpress Co., Ltd.

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Company Name:MedChemexpress Co., Ltd.

Business Type:Chemical manufacturer

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Country/Region:USA

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Introduction of MedChemexpress Co., Ltd.

Web: www.medchemexpress.com TEL:609-228-6898 Fax:609-228-5909 Email:sales@medchemexpress.com

Products of MedChemexpress Co., Ltd.

  • Chemical Name: AMG 837 (calcium hydrate)
    CAS No.: 1259389-38-2 Purity: >98% Appearances:
    Brand: Synonyms: AMG-837 calcium hydrate;AMG... Quality Control & MSDS Files:
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    Brief introduction:

    AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the rac...

  • Chemical Name: AMG 837 (sodium salt)
    CAS No.: 865231-45-4 Purity: >98% Appearances:
    Brand: Synonyms: AMG-837 sodium salt;AMG837 ... Quality Control & MSDS Files:
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    Brief introduction:

    AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic...

  • Chemical Name: NVP-AAM077
    CAS No.: 459836-30-7 Purity: >98% Appearances:
    Brand:MedChemExpress Synonyms: Phosphonic acid, [[[(1S)-1-... Quality Control & MSDS Files:
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    PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM). IC50 value: 270 nM(hNMDA A1/A2) [1] Target: NR2A antagonist in vitro: PEAQX has a high binding affinity for NMDA receptors (IC50=8 nM), and a functional prefer...

  • Chemical Name: LY2857785
    CAS No.: 1619903-54-6 Purity: >98% Appearances: White to off-white Solid
    Brand:MedChemExpress Synonyms: LY 2857785;LY-2857785; (1r,... Quality Control & MSDS Files:
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    Brief introduction:

    LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines. IC50 value: Target: CDK9 inhibitor LY2857785 inhibits the growth of a broad panel of cancer cell lines, and i...

  • Chemical Name: (R)-(+)-Etomoxir (sodium salt)
    CAS No.: 828934-41-4 Purity: >98% Appearances:
    Brand: Synonyms: (+)-Etomoxir sodium salt; s... Quality Control & MSDS Files:
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    Brief introduction:

    (R)-(+)-Etomoxir (sodium salt) is a potent inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria; shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

  • Chemical Name: IM-12
    CAS No.: 1129669-05-1 Purity: >98% Appearances: Light yellow to yellow Solid
    Brand:MedChemExpress Synonyms: IM 12;IM12; 3-((4-fluorophe... Quality Control & MSDS Files:
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    IM-12 is a potent GSK-3β inhibitor with IC50 of 53 nM; shows a significant activity in several biological tests which was comparable or even outplayed the effects of the known SB-216763. IC50 value: 53 nM [1] Target: GSK-3β inhibitor IM-12 acts as GSK-3b inhibitor resulting in the activation of downstream components of canonical Wnt...

  • Chemical Name: Nexturastat A
    CAS No.: 1403783-31-2 Purity: >98% Appearances:
    Brand: Synonyms: 4-((1-butyl-3-phenylureido)... Quality Control & MSDS Files:
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    Brief introduction:

    Nexturastat A is a potent and selective HDAC6 inhibitor with IC50 of 5 nM; no inhibition on other HDAC forms. IC50 value: 5 nM [1] Target: HDAC6 inhibitor Nexturastat A displayed low micromolar activity compared to the low nanomolar activity against HDAC6. Moreover, it also demonstrated high levels of selective inhibition against me...

  • Chemical Name: kb-NB77-78
    CAS No.: 1350622-33-1 Purity: >98% Appearances:
    Brand: Synonyms: 9-((tert-butyldimethylsilyl... Quality Control & MSDS Files:
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    Brief introduction:

    kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).

  • Chemical Name: Demethyldolastin 10 hydrochloride
    CAS No.: 173441-26-4 Purity: >98% Appearances: White to off-white solid
    Brand:MedChemExpress Synonyms: (S)-N-((3R,4S,5S)-3-methoxy... Quality Control & MSDS Files:
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    Brief introduction:

    Monomethyl auristatin D Hcl (MMAD Hcl), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate. IC50 value: Target: Tubulin; ADCs toxin For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T...

  • Chemical Name: HG6-64-1
    CAS No.: 1315329-43-1 Purity: >98% Appearances: Light yellow to yellow Solid
    Brand:MedChemExpress Synonyms: HG-6-64-1;HG 6-64-1; (E)-N-... Quality Control & MSDS Files:
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    HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor; more information can be found in Patent WO 2011090738. IC50 value: Target: B-Raf Preparation of pyrazine and pyrrolo[2,3-b]pyridine derivatives as b-raf kinase inhibitors useful in the treatment of cancer and proliferative diseases By Gray, Nathanael S. From PCT ...

  • Chemical Name: 4SC-202 (free base)
    CAS No.: 910462-43-0 Purity: >98% Appearances:
    Brand: Synonyms: 4SC 202 free base;4SC202 fr... Quality Control & MSDS Files:
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    Brief introduction:

    4SC-202 free base is an orally available potent HDACi specific for class I HDAC isoenzymes(NO HDAC8) with IC50s of 1.2/1.12/0.57 uM for HDAC1/2/3; high selectivity over ClassIIa/IIb/III HDACs. IC50 value: Target: HDAC1/2/3 The novel HDACi 4SC-202 is an orally available potent HDACi specific for class I HDAC isoenzymes. It has shown ...

  • Chemical Name: Dictamine
    CAS No.: 484-29-7 Purity: >98% Appearances:
    Brand: Synonyms: 4-Methoxyfuro[2,3-b]quinoli... Quality Control & MSDS Files:
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    Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi. IC50 value: Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a min...

  • Chemical Name: Arg-Gly-Asp-Ser
    CAS No.: 91037-65-9 Purity: >98% Appearances:
    Brand: Synonyms: RGDS peptide;Fibronectin In... Quality Control & MSDS Files:
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    Brief introduction:

    Arg-Gly-Asp-Ser(RGDS peptide) is an integrin binding sequence that inhibits integrin receptor function; decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. IC50 value: Target: intergrin in vitro: The RGDS-modified surface ...

  • Chemical Name: Defactinib
    CAS No.: 1073154-85-4 Purity: >98% Appearances: White to off-white Solid
    Brand:MedChemExpress Synonyms: VS-6063;VS6063;VS 6063; N-m... Quality Control & MSDS Files:
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    Brief introduction:

    Defactinib(VS-6063; PF-04554878) is a potent FAK phosphorylation inhibitor; overcomes YB-1–mediated paclitaxel resistance by an AKT-dependent pathway. IC50 value: Target: FAK inhibitor VS-6063 inhibited FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. The combination of VS-6063 and paclitaxel markedly de...

  • Chemical Name: YH239-EE
    CAS No.: 1364488-67-4 Purity: >98% Appearances:
    Brand: Synonyms: YH 239-EE;YH 239 EE; ethyl ... Quality Control & MSDS Files:
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    Brief introduction:

    YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent IC50 value: Target: MDM2/p53 YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis v...

  • Chemical Name: PI-1840
    CAS No.: 1401223-22-0 Purity: >98% Appearances: White to off-white Solid
    Brand:MedChemExpress Synonyms: PI 1840;PI1840; N-isopropyl... Quality Control & MSDS Files:
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    Brief introduction:

    PI-1840 is a potent and selective inhibitor for chymotrypsin-like (CT-L) (IC50 value = 27 ± 0.14 nM) over trypsin-like and peptidylglutamyl peptide hydrolyzing (IC50 values >100 μM) activities of the proteasome. IC50 value: 27 nM(CT-L activities of the proteasome) [1] Target: CT-L inhibitor in vitro: PI-1840 is over 100-fold more s...

  • Chemical Name: Buparvaquone
    CAS No.: 88426-33-9 Purity: >98% Appearances:
    Brand: Synonyms: Butalex; 2-((4-(tert-butyl)... Quality Control & MSDS Files:
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    Brief introduction:

    Buparvaquone(Butalex) is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone; it is a promising compound for the therapy and prophylaxis of all forms of theileriosis.

  • Chemical Name: Methanone, [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-
    CAS No.: 1268454-23-4 Purity: >98% Appearances:
    Brand:MedChemExpress Synonyms: (6-(2-aminobenzo[d]oxazol-5... Quality Control & MSDS Files:
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    Brief introduction:

    MLN1117 (INK1117) is a selective p110α inhibitor with IC50 of 15 nM. IC50 value: 15 nM Target: p110α in vitro: MLN1117 also inhibits p110β (IC50=4.5μM), p110γ (IC50=1.9μM), p110δ (IC50=13.39μM), and mTOR (IC50=1.67μM). MLN1117 inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC50 values around 2 μM, ...

  • Chemical Name: NVP-QAV-680
    CAS No.: 872365-16-7 Purity: >98% Appearances:
    Brand:MedChemExpress Synonyms: NVP-QAV680;NVP-QAV 680;NVP-... Quality Control & MSDS Files:
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    Brief introduction:

    NVP-QAV680 is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM by 3H-PGD2 filtration binding assay. IC50 value: 36 nM [1] Target: CRTh2 antagonist in vitro: NVP-QAV680 was found to be inactive against eotaxin stimulated shape change mediated through the CCR-3 receptor. NVP-QAV680 elicited a potent inhibitory respons...