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Axon Medchem BV

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Basic Information

Company Name:Axon Medchem BV

Business Type:Chemical manufacturer

Total NO.Employees:

Country/Region:Netherlands

Certificates:

Year Established:

Introduction of Axon Medchem BV

Axon Medchem is a leading European service platform for medicinal chemistry, spinned-off from Axon Biochemicals BV. Together with Axon Biochemicals BV, it conducts business operations as a contract research organization (CRO) in medicinal chemistry.Subsequent to the spin-off in 2006, Axon Medchem has developed as a prime source of high-value life science products, providing Axon Ligands™ for pharmaceutical research as world-wide recognized drug standards. Therefore, we aim to keep up with relevant scientific publications in order to serve potential customers with the latest advances in the field of the development of novel therapeutics for known diseases and pathologies like psychiatric disorders, oncology, Alzheimer's and Parkinson's disease, diabetes, inflammatory diseases, and many others.

Web: www.axonmedchem.com TEL:+31 50 3118007 Fax:+31 50 3600390 Email:[email protected];[email protected]

Products of Axon Medchem BV

  • Chemical Name: IM-12
    CAS No.: 1129669-05-1 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: IM 12;IM12; 3-((4-fluorophe... Quality Control & MSDS Files:
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    Brief introduction:

    IM-12 is an inhibitor of <b>GSK-3β</b>, with an <b>IC<sub>50</sub></b> of 53 nM, and also enhances Wnt signalling.

  • Chemical Name: (R)-(-)-Rolipram
    CAS No.: 85416-75-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: (R)-Rolipram;(-)-Rolipram; ... Quality Control & MSDS Files:
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    Brief introduction:

    (R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 0.22 uM; 2.5-fold more potent than (+)-rolipram (IC50= 2.58 uM) in inhibiting membrane-bound PDE 4. IC50 value: Target: PDE4 in vitro: In intact eosinophils, (-)-rolipram (EC50 = 0.19 +/- 0.02 microM) was 10-fold more potent than (+)-rolipram (EC50 = 1.87 ...

  • Chemical Name: MI 2
    CAS No.: 1047953-91-2 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: MALT1 inhibitor Quality Control & MSDS Files:
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    Brief introduction:

    MI 2 (MALT1 inhibitor) is an irreversible <b>MALT1</b> protease inhibitor with an <b>IC<sub>50</sub></b> of 5.84 μM.

  • Chemical Name: AK-7
    CAS No.: 420831-40-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AK 7;AK7; 3-(azepan-1-ylsul... Quality Control & MSDS Files:
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    Brief introduction:

    AK-7 is a selective and brain-permeable SIRT2 inhibitor; is neuroprotective in Huntington disease mouse models. IC50 value: Target: SIRT2 AK-7 treated R6/2 mice performed significantly better than vehicle treated littermates on the accelerating rotarod at 8 and 11 weeks of age.

  • Chemical Name: FR 180204
    CAS No.: 865362-74-9 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: FR 180204;FR-180204; 5-(2-p... Quality Control & MSDS Files:
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    Brief introduction:

    FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively. IC50 value: 0.31 uM/0.14 uM(Ki for ERK1/ERK2); 0.51uM/0.33 μM(ERK1/ERK2) [1] [2] Target: ERK1/2 inhibitor in vi...

  • Chemical Name: iCRT 14
    CAS No.: 677331-12-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: iCRT14;iCRT-14; (Z)-5-((2,5... Quality Control & MSDS Files:
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    Brief introduction:

    iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). IC50 value: 40.3 nM [1] Target: Wnt inhibitor Thought to directly influence the interaction between β-catenin and TCF4.

  • Chemical Name: SJ-172550
    CAS No.: 431979-47-4 Purity: Appearances: Pink to red Solid
    Brand: Synonyms: SJ172550;SJ 172550; (E)-met... Quality Control & MSDS Files:
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    Brief introduction:

    SJ-172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. IC50 value: 0.84 uM(EC50) [1] Target: MDMX inhibitor in vitro: Unlike SJ-134433 and SJ-044557, SJ-172550 was stable in solution and did not modify the MDMX prot...

  • Chemical Name: Eluxadoline
    CAS No.: 864821-90-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: JNJ 27018966;JNJ27018966;JN... Quality Control & MSDS Files:
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    Brief introduction:

    Eluxadoline is a mixed <b>μ-</b> and <b>κ-opioid receptor</b> agonist and <b>δ-opioid receptor</b> antagonist.

  • Chemical Name: GW311616 (hydrochloride)
    CAS No.: 197890-44-1 Purity: Appearances:
    Brand: Synonyms: GW-311616 hydrochloride;GW ... Quality Control & MSDS Files:
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    Brief introduction:

    GW311616A(GW311616 Hcl) is a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase(HNE) with IC50 of 22 nM. IC50 value: 22 nM [1] Target: neutrophil elastase The HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values >100 uM for trypsin, cathepsin G, and plasmin...

  • Chemical Name: Palbociclib (isethionate)
    CAS No.: 827022-33-3 Purity: Appearances: Light yellow to yellow Solid
    Brand: Synonyms: PD0332991 isethionate;PD-03... Quality Control & MSDS Files:
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    Brief introduction:

    Palbociclib isethionate(PD-0332991 isethionate) is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM), having no activity against a panel of 36 additional protein kinases. IC50 value: 11 nM/16 nM (Cdk4/Cdk6) [1] Target: Cdk4/Cdk6 in vitro: ATP competitive inhibitor of Cdk4.

  • Chemical Name: CID755673
    CAS No.: 521937-07-5 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: CID 755673;CID-755673; 7-hy... Quality Control & MSDS Files:
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    Brief introduction:

    CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms. IC50 value: 182 nM [1] Target: PKD in vitro: In cell-based assays, CID755673 blocked phorbol ester-induced endogenous PKD1 activatio...

  • Chemical Name: RTA-408
    CAS No.: 1474034-05-3 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Omaveloxolone Quality Control & MSDS Files:
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    Brief introduction:

    RTA-408 is an antioxidant inflammation modulator (AIM), which activates <b>Nrf2</b> and suppresses nitric oxide (NO).

  • Chemical Name: Difluprednate
    CAS No.: 23674-86-4 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Durezol; (6S,8S,9R,10S,11S,... Quality Control & MSDS Files:
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    Brief introduction:

    Difluprednate(Durezol) is a corticosteroid, approved difluprednate for the treatment of post-operative ocular inflammation and pain. IC50 value: Target: Difluprednate ophthalmic emulsion 0.05% is also being studied in other ocular inflammatory diseases, including a U.S.

  • Chemical Name: PS48
    CAS No.: 1180676-32-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: PS 48;PS-48; (Z)-5-(4-chlor... Quality Control & MSDS Files:
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    Brief introduction:

    PS48 is an activator of <b>PDK1</b> with an <b>AC<sub>50</sub></b> of 8 μM.

  • Chemical Name: AZD1981
    CAS No.: 802904-66-1 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: AZD 1981;AZD-1981; 2-(4-ace... Quality Control & MSDS Files:
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    Brief introduction:

    AZD1981 is a potent, selective <b>CRTh2 (DP2) receptor</b> antagonist with <b>IC50</b> of 4 nM, showing &gt;1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. Phase 2.

  • Chemical Name: SB-334867 (free base)
    CAS No.: 792173-99-0 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: SB334867A free base;SB33486... Quality Control & MSDS Files:
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    Brief introduction:

    SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with a pKb value of 7.2. IC50 value: 7.2 (pKb) [1] Target: orexin OX1 receptor in vitro: SB-334867-A inhibited the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses (pK(B)=7.27+/-0.04 and 7.23+/-0.03 respectively, n=8), but had no effect on...

  • Chemical Name: DBeQ
    CAS No.: 177355-84-9 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: JRF 12;JRF12;JRF-12; N2,N4-... Quality Control & MSDS Files:
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    Brief introduction:

    DBeQ(JRF-12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM. IC50 value: 1.5 uM Target: p97 in vitro: DBeQ blocks UbG76V-GFP, ODD-Luc and Luc-ODC degradation with IC50 of 2.6 μM, 56 μM and 45 μM in HeLa cells.

  • Chemical Name: (R,R)-reboxetine (mesylate)
    CAS No.: 105017-39-8 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: Quality Control & MSDS Files:
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  • Chemical Name: DMOG
    CAS No.: 89464-63-1 Purity: Appearances: Light yellow to yellow Oil
    Brand: Synonyms: Dimethyloxallyl Glycine; me... Quality Control & MSDS Files:
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    Brief introduction:

    Dimethyloxallyl Glycine(DMOG) is a cell permeable, competitive inhibitor of HIF-PH(HIF-1α prolyl hydroxylase). IC50 value: Target: HIF-1α prolyl hydroxylase The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-...

  • Chemical Name: C-7280948
    CAS No.: 587850-67-7 Purity: Appearances: White to off-white Solid
    Brand: Synonyms: C 7280948 Quality Control & MSDS Files:
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    Brief introduction:

    C7280948 is an inhibitor of histone arginine methyltransferase PRMT1 with IC50 values of 12.75 uM.

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