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MK-0249

(CAS: 862309-06-6)

Suppliers of MK-0249

Company Name Email Tel Country
CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD696/1mg () USD1380/5mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD696/1mg () USD1380/5mg ()

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

MedKoo Biosciences, Inc. [email protected].com 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD696/1mg () USD1380/5mg ()

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Background Information of MK-0249

MK-0249 is a potent histamine H3 receptor antagonist, with Ki of 1.7 nM for human H3.

Solubility of MK-0249

Solubility Sources

Storage Condition of MK-0249

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
MK-0249 Merck Sharp & Dohme Corp. Alzheimer's Disease|Dementia 2009/4/01 Phase 1
MK-0249 Merck Sharp & Dohme Corp. Paranoid Schizophrenia 2007/12/01 Phase 2
MK-0249 Merck Sharp & Dohme Corp. Alzheimer's Disease 2006/11/01 Phase 2
MK-0249 Merck Sharp & Dohme Corp. Sleep Apnea, Obstructive|Hypopnea Syndrome|Excessive Daytime Sleepiness 2008/2/01 Phase 2
MK-0249 Merck Sharp & Dohme Corp. Attention-Deficit/Hyperactivity Disorder (ADHD) 2007/7/01 Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
431.45 C23H24F3N3O2 862309-06-6 MK0249;MK 0249; 2-methyl-3-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)-5-(trifluoromethyl)quinazolin-4(3H)-one

Structure Information of MK-0249

Smiles O=C1N(C2=CC=C(OCCCN3CCCC3)C=C2)C(C)=NC4=C1C(C(F)(F)F)=CC=C4
InChI InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3

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Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:Soluble in DMSO, not in water
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Reference

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