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Lurbinectedin

(CAS: 497871-47-3)

Suppliers of Lurbinectedin

Company Name Email Tel Country
BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD1800/1mg () USD3360/2mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD1800/1mg () USD3360/2mg ()
Quality Control & MSDS Files: LCMS NP-HPLC HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD1800/1mg () USD3360/2mg ()

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Background Information of Lurbinectedin

Lurbinectedin (PM01183) is a new DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.

Solubility of Lurbinectedin

Solubility Sources
DMSO: 10 mM CHEMSCENE, LLC
DMSO: 10 mM MedChemexpress Co., Ltd.

Storage Condition of Lurbinectedin

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [NP-HPLC] [HNMR] MedChemexpress Co., Ltd.

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Lurbinectedin PharmaMar Advanced Solid Tumors 2015/8/01 Phase 2
Lurbinectedin PharmaMar Solid Tumors 2015/8/01 Phase 1
Lurbinectedin PharmaMar Advanced Solid Tumors 2014/7/30 Phase 1
Lurbinectedin PharmaMar Metastatic Breast Cancer|Pancreatic Cancer|Metastatic Colorectal Cancer 2013/4/01 Phase 1
Lurbinectedin PharmaMar Ovarian Cancer 2015/5/01 Phase 3
Lurbinectedin PharmaMar Non-Small Cell Lung Cancer (NSCLC) 2013/10/01 Phase 2
Lurbinectedin PharmaMar Small-cell Lung Cancer 2016/7/01 Phase 3
Lurbinectedin PharmaMar Advanced Solid Tumors 2016/5/06 Phase 1
Lurbinectedin PharmaMar Specific Advanced Solid Tumors 2011/5/01 Phase 1
Lurbinectedin PharmaMar Endometrial Adenocarcinomas|Neuroendocrine Tumors|Small-cell Lung Cancer With Less Than 2 Prior Cytotoxic-containing Lines of Therapy 2011/5/25 Phase 1
Lurbinectedin PharmaMar ADVANCED SOLID TUMORS 2009/3/01 Phase 1
Lurbinectedin PharmaMar Acute Leukemia 2011/5/01 Phase 1
Lurbinectedin PharmaMar Major Advanced Solid Tumors Other Than Colorectal 2011/11/01 Phase 1
Lurbinectedin PharmaMar Breast Cancer 2012/12/01 Phase 2
Lurbinectedin PharmaMar Breast Cancer|Ovarian Cancer|Gynecological Cancer|Head and Neck Carcinoma|Non-small Cell Lung Cancer|Small Cell Lung Cancer|Non-squamous Cell Lung Cancer 2013/9/01 Phase 1
Lurbinectedin Massachusetts General Hospital|Dana-Farber Cancer Institute|PharmaMar Metastatic Sarcoma 2015/8/01 Phase 2
Lurbinectedin Poveda, Andrés, M.D.|AstraZeneca|PharmaMar Advanced Cancer|Ovarian Cancer|Endometrial Cancer|Breast Cancer 2015/7/01 Phase 1|Phase 2
Lurbinectedin - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
784.87 C41H44N4O10S 497871-47-3 PM01183;PM-01183;PM 01183;

Structure Information of Lurbinectedin

Smiles O[[email protected]@H]([[email protected]@](CC1=CC(C)=C2OC)([H])N(C)[[email protected]]3([H])C1=C2O)N([[email protected]](COC4=O)([H])C5=C(OCO6)C6=C7C)[[email protected]@]3([H])[[email protected]@](SC[[email protected]@]4(NCC8)C9=C8C%10=CC(OC)=CC=C%10N9)([H])C5=C7OC(C)=O
InChI InChI=1S/C41H44N4O10S/c1-17-11-20-12-25-39(48)45-26-14-52-40(49)41(38-22(9-10-42-41)23-13-21(50-5)7-8-24(23)43-38)15-56-37(31(45)30(44(25)4)27(20)32(47)33(17)51-6)29-28(26)36-35(53-16-54-36)18(2)34(29)55-19(3)46/h7-8,11,13,25-26,30-31,37,39,42-43,47-48H,9-10,12,14-16H2,1-6H3/t25-,26-,30+,31+,37+,39-,41+/m0/s1

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Chemical and Physical Properties

Appearance: Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:Soluble in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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