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VU0357017 (hydrochloride)

(CAS: 1135242-13-5)

Suppliers of VU0357017 (hydrochloride)

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98 % Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD84/5mg () USD144/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD84/5mg () USD144/10mg ()
Quality Control & MSDS Files: LCMS HNMR

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD84/5mg () USD144/10mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of VU0357017 (hydrochloride)

VU0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15). IC50 value: 477 ± 172 nM (EC50) [1] Target: M1 in vitro: VU0357017 is a M1-selective agonists that appear to activate M1 through actions at an allosteric site.

Solubility of VU0357017 (hydrochloride)

Solubility Sources
DMSO: ≥ 33 mg/mL CHEMSCENE, LLC
DMSO: ≥ 33 mg/mL MedChemexpress Co., Ltd.
Soluble to 25 mM in water and to 5 mM in DMSO Tocris Bioscience Inc.

Storage Condition of VU0357017 (hydrochloride)

Storage Condition Sources
Store in a tightly closed container, in a cool and dry place. MedChemexpress Co., Ltd.
Store at +4°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
VU0357017 (hydrochloride) - Not Found
VU0357017 (hydrochloride) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
369.89 C18H28ClN3O3 1135242-13-5 CID-25010775;VU-0357017 hydrochloride;VU 0357017 hydrochloride; ethyl 4-((2-(2-methylbenzamido)ethyl)amino)piperidine-1-carboxylate hydrochloride

Structure Information of VU0357017 (hydrochloride)

Smiles O=C(N1CCC(NCCNC(C2=CC=CC=C2C)=O)CC1)OCC.[H]Cl
InChI InChI=1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H

Related Products

Other Form Products of VU0357017 (hydrochloride)

Name CAS Formula Suppliers
VU0357017 1135681-23-0 C18H27N3O3 1

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:DMSO:1.85mg/mL;5mM;water:9.25mg/mL;25mM;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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