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PD0325901

(CAS: 391210-10-9)

Suppliers of PD0325901

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand:

Price and Availability: USD19/1mg ()

AbMole BioScience [email protected] 1-800-660-8580 USA

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Adipogen Corporation [email protected] (858) 457-8383 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: 98% Brand: Tocris

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Price and Availability: USD198/100mg (In stock)

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/5mg () USD108/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Eastbang Pharmaceuticals Science & Technology Co., Ltd [email protected] +86-20-34703959 CHINA

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LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

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Price and Availability: USD44/5mg (In stock) USD67/10mg (In stock) USD122/25mg (In stock) USD188/50mg (In stock) USD292/100mg (In stock) USD479/200mg (In stock) USD972/500mg (In stock) USD1440/1g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD108/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD70/5mg (In stock) USD120/10mg (In stock) USD140/10mM/1mLIn DMSO (In stock) USD270/25mg (In stock) USD770/100mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HPLC HPLC HNMR HPLC HNMR HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD60/5mg () USD108/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD78/5mg () USD102/10mg () USD144/25mg () USD198/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Background Information of PD0325901

PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM. IC50 value: Target: MEK PD0325901 is a selective MEK1 and MEK2 inhibitor.

Solubility of PD0325901

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
DMSO: ≥ 20 mg/mL, H2O: < 1 mg/mL CHEMSCENE, LLC
Soluble in DMSO at 12 mg/mL; soluble in ethanol at 6.3 mg/mL with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 μM buffers, serum, or other additives may increase or decrease the aqueous so. LC Laboratoies
DMSO: ≥ 20 mg/mL, H2O: < 1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 96 mg/mL (199.09 mM); Ethanol40 mg/mL (82.95 mM); Water<1 mg/mL (<1 mM); In vivo 30% PEG 400+5% Tween 80+ddH2O10mg/mL Selleck Chemicals LLC

Storage Condition of PD0325901

Storage Condition Sources
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies
4°C MedChemexpress Co., Ltd.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
PD0325901 Pfizer Inc Non-small-cell lung cancer 2005/11/30 2007/3/23 Phase 2 Clinical
PD0325901 Pfizer Inc Stage IV melanoma 2004/2/29 2013/7/31 Phase 2 Clinical
PD0325901 Pfizer Inc Metastatic breast cancer 2004/2/29 2013/7/31 Phase 2 Clinical
PD0325901 Pfizer Inc Metastatic colon cancer 2004/2/29 2013/7/31 Phase 2 Clinical
PD0325901 Pfizer Inc Advanced solid tumor 2011/10/31 2014/11/30 Phase 1 Clinical
PD0325901 - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
482.19 C16H14F3IN2O4 391210-10-9 PD 0325901; PD325901; PD-0325901; (R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide

Structure Information of PD0325901

Smiles O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2F)F)NOC[[email protected]](O)CO
InChI InChI=1S/C16H14F3IN2O4/c17-11-3-2-10(16(25)22-26-7-9(24)6-23)15(14(11)19)21-13-4-1-8(20)5-12(13)18/h1-5,9,21,23-24H,6-7H2,(H,22,25)/t9-/m1/s1

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Safety Data of PD0325901

Hazard Symbols:T,N Risk Statements:25-48-50 Safety Statements:22-36/37/39-61
Transport Information: HS Code: RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance:White to off-white solid Melting point:112-114°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,96 mg/mL(199.09 mM);In vitro:Ethanol,40 mg/mL(82.95 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):30% PEG 400+5% Tween 80+ddH2OFor best results, us
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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