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Perifosine

(CAS: 157716-52-4)

Suppliers of Perifosine

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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Astatech, Inc. [email protected] +1 (215) 785-3197 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD72/5mg () USD96/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

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Price and Availability: USD63/5mg (In stock) USD99/10mg (In stock) USD178/25mg (In stock) USD275/50mg (In stock) USD444/100mg (In stock) USD716/200mg (In stock) USD1130/500mg (In stock) USD1622/1g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD72/5mg () USD96/10mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD147/5mg (In stock) USD270/10mg (In stock) USD870/50mg (In stock) USD1970/200mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HNMR HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD72/5mg () USD96/10mg ()

Shanghai Paulshinechem Co., Ltd. [email protected] +86 (21) 3778-8663 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: 1 Brand: TargetMol

Price and Availability: USD95/10mg () USD158/25mg () USD238/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Background Information of Perifosine

Perifosine (KRX-0401; D-21266; NSC 639966) is a novel Akt inhibitor with IC50 of 4.7 μM, targets pleckstrin homology domain of Akt. IC50 value: Target: Akt in vitro: Perifosine develops anti-proliferative properties with IC50 of 0.6-8.9 μM in immortalized keratinocytes (HaCaT), and head and neck squamous carcinoma cells [1].

Solubility of Perifosine

Solubility Sources
Limited solubility Apexbio Technology LLC
Very poorly soluble in DMSO; soluble in ethanol at 200 mg/mL; soluble in water at 50 mg/mL with warming; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO <1.2mg/mL Water ≥12mg/mL Ethanol ≥90mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro Water 8 mg/mL (17.32 mM); Ethanol15 mg/mL (32.49 mM); DMSO<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W30 mg/mL Selleck Chemicals LLC

Storage Condition of Perifosine

Storage Condition Sources
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways PI3K/Akt/mTOR Autophagy
Target Akt Autophagy
Research Area Cancer
Indications Lymphoma Solid tumor Renal tumor Leukemia Renal cell carcinoma

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Perifosine AEterna Zentaris Inc Lymphoma 2005/1/31 2011/9/30 Phase 2 Clinical
Perifosine AEterna Zentaris Inc Solid tumor 2005/1/31 2011/9/30 Phase 2 Clinical
Perifosine AEterna Zentaris Inc Renal tumor 2007/7/31 2011/10/31 Phase 2 Clinical
Perifosine AEterna Zentaris Inc Leukemia 2006/10/31 2011/10/31 Phase 2 Clinical
Perifosine AEterna Zentaris Inc Renal cell carcinoma 2007/3/31 2011/10/31 Phase 2 Clinical
Perifosine - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
461.66 C25H52NO4P 157716-52-4 (1,1-Dimethylpiperidin-1-ium-4-yl) octadecyl phosphate; 4-((Hydroxy(octadecyloxy)phosphinyl)oxy)-1,1-dimethylpiperidinium inner salt; 1,1-dimethylpiperidin-1-ium-4-yl octadecyl phosphate

Structure Information of Perifosine

Smiles O=P(OCCCCCCCCCCCCCCCCCC)([O-])OC1CC[N+](C)(C)CC1
InChI InChI=1S/C25H52NO4P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24-29-31(27,28)30-25-20-22-26(2,3)23-21-25/h25H,4-24H2,1-3H3

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:Ethanol,15 mg/mL(32.49 mM);In vitro:Water,8 mg/mL(17.32 mM);In vitro:DMSO,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):waterFor best results, use promptly after mixing.,8
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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