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SB-743921

(CAS: 940929-33-9)

Suppliers of SB-743921

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD264/10mg () USD815/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD264/10mg () USD815/50mg ()
Quality Control & MSDS Files: MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Quality Control & MSDS Files: CoA HNMR CNMR HPLC LCMS MSDS

ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD170/5mg (In stock) USD320/10mg (In stock) USD380/10mM/1mLIn DMSO (In stock) USD970/50mg (In stock) USD2470/200mg (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD264/10mg () USD815/50mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD142/5mg () USD256/10mg () USD613/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of SB-743921

SB-743921 is a second generation, highly potent and active KSP inhibitor with Ki of 0.1 nM; no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. IC50 Value: 0.1 nM( Ki) Target: Ksp in vitro: The Ki of SB 743921 for human and mouse KSP is 0.1 nM and 0.12 nM, respectively, while the Ki of SB 743921 for other kinesins including MKLP1, Kin2 is more than 70 μM.

Solubility of SB-743921

Solubility Sources
DMSO ≥110mg/mL Water ≥20mg/mL Ethanol ≥110mg/mL MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 111 mg/mL (200.53 mM); Ethanol111 mg/mL (200.53 mM); Water22 mg/mL (39.74 mM); In vivo Saline pH5.030 mg/mL Selleck Chemicals LLC
Soluble to 100 mM in DMSO Tocris Bioscience Inc.

Storage Condition of SB-743921

Storage Condition Sources
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.
Store at -20°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[CoA] [HNMR] [CNMR] [HPLC] [LCMS] MedKoo Biosciences, Inc.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage Cytoskeleton
Target Kinesin
Research Area Cancer
Indications Non-Hodgkin lymphoma Hodgkins disease Solid tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
SB-743921 Cytokinetics Inc Non-Hodgkin lymphoma 2006/4/30 2010/7/31 Phase 2 Clinical
SB-743921 Cytokinetics Inc Hodgkins disease 2006/4/30 2010/7/31 Phase 2 Clinical
SB-743921 GlaxoSmithKline plc Solid tumor 2004/4/30 Phase 1 Clinical
SB-743921 - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
553.52 C31H34Cl2N2O3 940929-33-9 SB743921; SB 743921; (R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-4H-chromen-2-yl)-2-methylpropyl)-4-methylbenzamide hydrochloride

Structure Information of SB-743921

Smiles ClC1=CC2=C(C(C(CC3=CC=CC=C3)=C([[email protected]@H](C(C)C)N(C(C4=CC=C(C=C4)C)=O)CCCN)O2)=O)C=C1.Cl
InChI InChI=1S/C31H33ClN2O3.ClH/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30;/h4-6,8-15,19-20,28H,7,16-18,33H2,1-3H3;1H/t28-;/m1./s1

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Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,111 mg/mL(200.53 mM);In vitro:Ethanol,111 mg/mL(200.53 mM);In vitro:Water,22 mg/mL(39.74 mM);In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):Saline pH5.0For best results, use pro
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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