• Search chemicals, activators, Inhibitors, APIs, intermediates and raw materials.

YM-155

(CAS: 781661-94-7)

Suppliers of YM-155

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand:

Price and Availability: USD15/1mg ()

AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: > 99% Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

ProbeChem [email protected] 86-21-80183644

Fax: 86-21-68860190Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD70/5mg (In stock) USD112/10mM/1mLIn DMSO (In stock) USD120/10mg (In stock) USD270/25mg (In stock) USD770/100mg (In stock)
Quality Control & MSDS Files: HPLC HPLC HPLC HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/5mg () USD84/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD67/10mg () USD132/25mg () USD234/50mg ()

Inquiry Online

Salutation: *Country:
*Customer: *Company Name:
*Email: *Request quantity:
Remarks:
 

Notice: Your contact information will be sent to selected suppliers.

* Required Fields.

Background Information of YM-155

YM155 (Sepantronium bromide) is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. IC50 Value: 0.54 nM Target: Survivin In vitro: YM155 is not sensitive to survivn gene promoter-driven luciferase reporter activity even at 30 μM.

Solubility of YM-155

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
Soluble in DMSO. LC Laboratoies
DMSO ≥85mg/mL Water ≥85mg/mL Ethanol ≥20mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 55 mg/mL (124.07 mM); Water89 mg/mL (200.77 mM); Ethanol6 mg/mL (13.53 mM); In vivo Saline30 mg/mL Selleck Chemicals LLC

Storage Condition of YM-155

Storage Condition Sources
Store at -20°C Apexbio Technology LLC
Store at or below -20 oC. LC Laboratoies

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
YM-155 Astellas Pharma Inc Metastatic breast cancer 2009/12/31 2013/6/30 Phase 2 Clinical
YM-155 Astellas Pharma Inc Stage III melanoma 2009/11/30 2012/8/31 Phase 2 Clinical
YM-155 Astellas Pharma Inc Stage IV melanoma 2009/11/30 2012/8/31 Phase 2 Clinical
YM-155 Astellas Pharma Inc Non-Hodgkin lymphoma 2009/11/30 2013/8/31 Phase 2 Clinical
YM-155 Astellas Pharma Inc Non-small-cell lung cancer 2006/12/31 2007/3/31 Phase 2 Clinical
YM-155 - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
443.29 C20H19BrN4O3 781661-94-7 YM155; Sepantronium bromide;YM 155; 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide

Structure Information of YM-155

Smiles O=C1C2=C(C(C3=CC=CC=C31)=O)[N+](CC4=NC=CN=C4)=C(C)N2CCOC.[Br-]
InChI InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1

Related Products

Other Form Products of YM-155

Name CAS Formula Suppliers
YM-155 (hydrochloride) 355406-09-6 C20H19ClN4O3 10
LTX-401 (trifluoroacetate) 1262851-71-7 C27H35F6N3O5 1
LTX-401 1398051-86-9 C23H35N3O 5
Carboxyspermidine 64817-93-2 C8H21Cl2N3O2 1
SMI-16a 587852-28-6 C13H13NO3S 4
AS-35 108427-72-1 C21H20N6O4 5
A-69412 123606-23-5 C7H10N2O3 3
Iralukast 151581-24-7 C38H37F3O8S 3
LY 345899 10538-99-5 C20H21N7O7 5
CM-4620 1713240-67-5 C19H11ClF3N3O3 4
SNS-062 1270014-40-8 C19H21ClN6O 5
8-epidiosbulbin E acetate 91095-48-6 C21H24O7 2

Recommended Products in Same Target

Name CAS Formula Suppliers
YM-155 (hydrochloride) 355406-09-6 C20H19ClN4O3 10
Pirarubicin (Hydrochloride) 95343-20-7 C32H38ClNO12 8
Berberine (chloride) 633-65-8 C20H18ClNO4 16
DMH-1 1206711-16-1 C24H20N4O 21
CB-839 1439399-58-2 C26H24F3N7O3S 16
H-89 (dihydrochloride) 130964-39-5 C20H22BrCl2N3O2S 11
Shikonin 517-89-5 C16H16O5 22
H 89 127243-85-0 C20H20BrN3O2S 12
Eupatilin 22368-21-4 C18H16O7 13
Isoalantolactone 470-17-7 C15H20O2 13
Scutellarein 529-53-3 C15H10O6 15
Leonurine 24697-74-3 C14H21N3O5 14
Berbamine (dihydrochloride) 6078-17-7 C37H42Cl2N2O6 20
Ruxolitinib (S enantiomer) 941685-37-6 C17H18N6 14
D-Glucosamine (Hydrochloride) 66-84-2 C6H14ClNO5 32
Schizandrin A 61281-38-7 C22H28O6 8
Schisandrol B 58546-54-6 C23H28O7 8
Schisandrol A 7432-28-2 C24H32O7 7
Icaritin 118525-40-9 C21H20O6 8
Bicyclol 118159-48-1 C19H18O9 9

Recommended Products in the Same Indication

Name CAS Formula Suppliers
CAL-101 870281-82-6 C22H18FN7O 19
Trametinib 871700-17-3 C26H23FIN5O4 21
PU-H71 873436-91-0 C18H21IN6O2S 9
Crizotinib 877399-52-5 C21H22Cl2FN5O 25
Ostarine 841205-47-8 C19H14F3N3O3 12
AT9283 896466-04-9 C19H23N7O2 21
AT-101 90141-22-3 C30H30O8 16
IDO5L 914471-09-3 C9H7ClFN5O2 16
Dovitinib 405169-16-6 C21H21FN6O 19
SB-590885 405554-55-4 C27H27N5O2 18
MK-0752 471905-41-6 C21H21ClF2O4S 16
Cyclophosphamide 50-18-0 C7H15Cl2N2O2P 19
N-Hydroxy-3-(3-phenylsulfamoylphenyl)acrylamide 414864-00-9 C15H14N2O4S 13
Retaspimycin 857402-23-4 C31H45N3O8 9
Retaspimycin (Hydrochloride) 857402-63-2 C31H46ClN3O8 10
Motesanib (Diphosphate) 857876-30-3 C22H29N5O9P2 20
Anamorelin (hydrochloride) 861998-00-7 C31H43ClN6O3 10
Litronesib 910634-41-2 C23H37N5O4S2 7
LY2603618 911222-45-2 C18H22BrN5O3 15
AT13387 912999-49-6 C24H31N3O3 19

Chemical and Physical Properties

Appearance:Light yellow to yellow solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:Water,89 mg/mL(200.77 mM);In vitro:DMSO,55 mg/mL(124.07 mM);In vitro:Ethanol,6 mg/mL(13.53 mM);In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):SalineFor best results, use promptly aft
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

Reference

[1].Iwasa, Tsutomu; Okamoto, Isamu; Suzuki, Minoru; Radiosensitizing Effect of YM155, a Novel Small-Molecule Survivin Suppressant, in Non-Small Cell Lung Cancer Cell Lines. Clinical Cancer Research (2008), 14(20), 6496-6504

[2].Satoh, Taroh; Okamoto, Isamu; Miyazaki, Masaki; Morinaga, Ryotaroh; Phase I Study of YM155, a Novel Survivin Suppressant, in Patients with Advanced Solid Tumors. Clinical Cancer Research (2009), 15(11), 3872-3880.

[3].Aoyama Y, Kaibara A, Takada A, Nishimura T, Katashima M, Sawamoto T.Population pharmacokinetic modeling of Sepantronium bromide (YM155), a small molecule survivin suppressant, in patients with non-small cell lung cancer, hormone refractory prostate cancer, or unresectable stage III or IV melanoma.Invest New Drugs. 2012 Aug 16.

[4].Yamauchi T, Nakamura N, Hiramoto M, Yuri M, Yokota H, Naitou M, Takeuchi M, Yamanaka K, Kita A, Nakahara T, Kinoyama I, Matsuhisa A, Kaneko N, Koutoku H, Sasamata M, Kobori M, Katou M, Tawara S, Kawabata S, Furuichi K.Sepantronium Bromide (YM155) induces disruption of the ILF3/p54(nrb) complex, which is required for survivin expression.Biochem Biophys Res Commun. 2012 Sep 7;425(4):711-6. Epub 2012 Jul 27.

[5].Aoyama Y, Nishimura T, Sawamoto T, Satoh T, Katashima M, Nakagawa K.Pharmacokinetics of sepantronium bromide (YM155), a small-molecule suppressor of survivin, in Japanese patients with advanced solid tumors: dose proportionality and influence of renal impairment.Cancer Chemother Pharmacol. 2012 Sep;70(3):373-80. Epub 2012 Jul 18.

Tags: buy YM-155 | YM-155 IC50 | YM-155 price | YM-155 cost | YM-155 solubility | YM-155 purchase | YM-155 manufacturer | YM-155 research buy | YM-155 order | YM-155 MSDS | YM-155 chemical structure | YM-155 Storage condition | YM-155 molecular weight | YM-155 mw | YM-155 datasheet | YM-155 supplier | YM-155 cell line | YM-155 NMR | YM-155 MS | YM-155 IR | YM-155 solubility | YM-155 Safe information | YM-155 Qc and Spectral Information | YM-155 Clinical Information | YM-155 Clinical Trial | YM-155 Route of Synthesis | YM-155 storage condition | YM-155 diseases and conditions | YM-155 flash point | YM-155 boiling point | YM-155 melting point | YM-155 storage condition | YM-155 brand