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Calcitriol

(CAS: 32222-06-3)

Suppliers of Calcitriol

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A.G. Scientific, Inc. [email protected] 858 452 9925 USA

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AOBIOUS INC [email protected] (508) 306-0937 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Affix Scientific [email protected] +1-510-936-6647 USA

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Price and Availability: USD1695/10g (In stock) USD2450/25g (In stock)
Quality Control & MSDS Files: CoA MSDS

Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD120/2mg () USD276/5mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Hydragon Pharma Co., Ltd. [email protected] +86 (21) 5021-5258 / 5021-8972 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD120/2mg () USD276/5mg ()
Quality Control & MSDS Files: HNMR HNMR HNMR HNMR HNMR NP-HPLC HNMR HNMR NP-HPLC NP-HPLC HNMR NP-HPLC NP-HPLC NP-HPLC HNMR HNMR HNMR NP-HPLC NP-HPLC NP-HPLC NP-HPLC NP-HPLC NP-HPLC HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Nectar Industrial Co., Ltd. [email protected] +86 (755) 8100-9345 China

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ProbeChem [email protected] 86-21-80183644

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Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: >95% Brand:

Price and Availability: USD91/5mg (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD120/2mg (In stock) USD270/5mg (In stock) USD500/10mM/1mLIn DMSO (In stock) USD1070/25mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC HNMR HPLC

ShangHai PuYi Chemical Co., Ltd. [email protected],[email protected] +86 (21) 5768-7505 ex 305 / +86 13601674297 China

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Shanghai Bocimed Pharmaceutical Co., Ltd. [email protected] +86 (21) 5895-4816 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD120/2mg () USD276/5mg ()

Shanghai Zhongkang Weiye Biological Science & Technology Co., Ltd. [email protected] +86 (21) 5158-1999 ex 801 China

Fax: +86 (21) 5158-1939Purity: Brand:

Sichuan Industrial Institute of Antibiotics Co., Ltd. [email protected] +86 (28) 8421-6070 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD86/2mg () USD156/5mg () USD298/10mg () USD498/25mg () USD887/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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UHN (Shanghai) Research & Development Co., Ltd. [email protected], [email protected] (86) 21-5895 8002 China

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Price and Availability: USD1240/10g (In stock)

Wonder Synthesis (Beijing) Science and Development Co., Ltd. [email protected],[email protected] +86 (10) 8482-6062 China

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Xi'an Fude Technology Co., Ltd. [email protected],[email protected] +86 (29) 8835-2856 China

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Zhangjiagang Sunrise Fine Chemical Co., Ltd. [email protected] +86 (574) 8797-0832 China

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Zhejiang Esun Chemical Co., Ltd. [email protected] +86 (571) 5628-6531 China

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Background Information of Calcitriol

Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). IC50 value: Target: vitamin D receptor Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) displays calcemic actions.

Solubility of Calcitriol

Solubility Sources
DMSO ≥83mg/mL Water <1mg/mL Ethanol ≥83mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 83 mg/mL (199.21 mM); Ethanol83 mg/mL (199.21 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC
Soluble in DMSO and in ethanol Tocris Bioscience Inc.

Storage Condition of Calcitriol

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Desiccate at -20°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HNMR] [NP-HPLC] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Others
Target VD/VDR
Research Area Cancer
Indications Proteinuria Psoriasis End stage renal disease Asthma

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Calcitriol Huashan Hospital Proteinuria 2013/3/31 2015/6/30 Phase 4 Clinical
Calcitriol Galderma SA Psoriasis 2013/3/31 2015/5/01 Phase 4 Clinical
Calcitriol Seoul National University Hospital 2013/1/31 2013/3/31 Phase 4 Clinical
Calcitriol Seoul National University Hospital End stage renal disease 2012/7/31 2013/1/31 Phase 4 Clinical
Calcitriol Kantonsspital Bruderholz Asthma 2008/8/31 2010/8/31 Phase 4 Clinical
Calcitriol - No Development Reported
Calcitriol - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
416.64 C27H44O3 32222-06-3 1,25-Dihydroxyvitamin D3; Rocaltrol; (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

Structure Information of Calcitriol

Smiles C=C1[[email protected]](C[[email protected]@H](C/C1=C/C=C2[[email protected]]3([[email protected]@](C)([[email protected]](CC3)[[email protected]@H](CCCC(C)(O)C)C)CCC/2)[H])O)O
InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1

Related Products

Other Form Products of Calcitriol

Name CAS Formula Suppliers
Calcitriol D6 78782-99-7 C27H38D6O3 6
HLCL-61 (hydrochloride) 1158279-20-9 C23H25ClN2O 13
Bay 41-4109 298708-81-3 C18H13ClF3N3O2 7
AT 130 211364-06-6 C22H22BrN3O5 3
Ro 41-1049 (hydrochloride) 127917-66-2 C12H13ClFN3OS 7
Ro 41-1049 127500-84-9 C12H12FN3OS 3
HLCL-61 586395-74-6 C23H24N2O 4
NTRC-0066-0 1817791-73-3 C33H39N7O2 3
LY3177833 1627696-51-8 C16H12FN5O 9
eFT508 1849590-01-7 C17H20N6O2 9
CPI-1205 1621862-70-1 C27H33F3N4O3 10
BAY-1436032 1803274-65-8 C26H30F3N3O3 7
eFT508 hydrochloride 1849590-02-8 C17H21ClN6O2 1
Bay 41-4109 (racemate) 298708-79-9 C18H13ClF3N3O2 6
Bay 41-4109 (less active enantiomer) 476617-51-3 C18H13ClF3N3O2 3

Recommended Products in Same Target

Name CAS Formula Suppliers
25,26-Dihydroxyvitamin D3 29261-12-9 C27H44O3 6
(24R)-MC 976 112828-09-8 C27H42O3 8
(24S)-24,25-Dihydroxyvitamin D3 55700-58-8 C27H44O3 8
Calcitriol Impurities D 103656-40-2 C28H46O3 5
Calcifediol (monohydrate) 63283-36-3 C27H44O2 16
Cholecalciferol 67-97-0 C27H44O 15
(24S)-MC 976 112849-14-6 C27H42O3 9
(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol C39H68O3Si2 5
VD3-D6 118584-54-6 C27H38D6O 5
VD2-D3 1217448-46-8 C28H41D3O 9
25-Hydroxy VD2-D6 1262843-46-8 C28H38D6O2 9
1alpha, 25-Dihydroxy VD2-D6 216244-04-1 C28H38D6O3 9
Calcipotriol (monohydrate) 147657-22-5 C27H42O4 13
Cholecalciferol 67-97-0 C27H44O 12
Calcitriol Impurities A 73837-24-8 C27H44O3 7
(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 910133-70-9 C27H40O3 4
Paricalcitol 131918-61-1 C27H44O3 20
MC 976 129831-99-8 C27H42O3 10
24R-Calcipotriol 112827-99-3 C27H40O3 7
MC 1046 126860-83-1 C27H38O3 8

Recommended Products in the Same Indication

Name CAS Formula Suppliers
AN-2728 906673-24-3 C14H10BNO3 16
BMS-582949 623152-17-0 C22H26N6O2 10
SCH 527123 473727-83-2 C21H23N3O5 14
Beclometasone dipropionate 5534-09-8 C28H37ClO7 19
Setipiprant 866460-33-5 C24H19FN2O3 9
Levalbuterol (tartrate) 661464-94-4 C30H48N2O12 9
Bardoxolone 218600-44-3 C31H41NO4 17
Bardoxolone (methyl) 218600-53-4 C32H43NO4 16
Cinacalcet (hydrochloride) 364782-34-3 C22H23ClF3N 15
Sotrastaurin 425637-18-9 C25H22N6O2 14
OC000459 851723-84-7 C21H17FN2O2 18
Aleglitazar (racemate) 475479-24-4 C24H23NO5S 6
Vilanterol (trifenatate) 503070-58-4 C44H49Cl2NO7 11
Apremilast 608141-41-9 C22H24N2O7S 14
Formoterol 67346-49-0 C19H24N2O4 7
Talarozole 201410-53-9 C21H23N5S 8
Formoterol (Fumarate) 43229-80-7 C19H24N2O4.1/2C4H4O4<䲧甙Ỵ甚 17
Dimethyl fumarate 624-49-7 C6H8O4 25
Cinacalcet 226256-56-0 C22H22F3N 14
VX-765 273404-37-8 C24H33ClN4O6 19

Safety Data of Calcitriol

Hazard Symbols:T+,Xn,F Risk Statements:26/27/28-63-36/37/38-20/21/22-11 Safety Statements:36/37/39-45-36-26-16-7
Transport Information: HS Code:29061900 RTECS:FZ4645000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:119-1210C
Boiling point: Flash Point:14 °C
Water Solubility: Solubility:In vitro:DMSO,83 mg/mL(199.21 mM);In vitro:Ethanol,83 mg/mL(199.21 mM);In vitro:Water,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:250-963-8
Optical Rotation: alpha:

Reference

[1].Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. Beer and Myrthue (2004)

[2].Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373.

[3].Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589.

[4].L. F. HILL , C. J. VAN DEN BERG & E. B. MAWER.Vitamin D Metabolism in Experimental Uraemia: Effects on Intestinal Transport 45Ca and on Formation of 1,25-Dihydroxycholecalciferol in Rat. nature new biology 232, 189-191

[5].Anthony W. Norman, James F. Myrtle, Ronald J, et al. 1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine. Science 2 July 1971: Vol. 173 no. 3991 pp. 51-54

[6].M. R. Haussler, D. W. Boyce, E. T. Littledike, et al. A Rapidly Acting Metabolite of Vitamin D3. PNAS January 1, 1971 vol. 68 no. 1 177-181

[7].James F. Myrtle, Mark R. Haussler, Anthony W. Norman. Evidence for the Biologically Active Form of Cholecalciferol in the Intestine. Evidence for the Biologically Active Form of Cholecalciferol in the Intestine. March 10, 1970 The Journal of Biological Chemistry, 245, 1190-1196.

[8].L. G. Raisz, C. L. Trummel, M. F. Holick, H. F. Deluca. 1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture. Science 18 February 1972: Vol. 175 no. 4023 pp. 768-769.

[9].Krishnan AV, Swami S, Feldman D.Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: Importance of mammary CYP27B1 for treatment and prevention.J Steroid Biochem Mol Biol. 2012 Aug 23.

[10].Alkharfy KM, Al-Daghri NM, Yakout SM, Ahmed M.Calcitriol Attenuates Weight-Related Systemic Inflammation and Ultrastructural Changes of the Liver in a Rodent Model.Basic Clin Pharmacol Toxicol. 2012 Aug 21.

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