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Alfacalcidol

(CAS: 41294-56-8)

Suppliers of Alfacalcidol

Company Name Email Tel Country
Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >98% Brand:

Price and Availability: USD730/25mg (In stock) USD1595/100mg (In stock)
Quality Control & MSDS Files: CoA MSDS

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 0.98 Brand: BOC Sciences

Price and Availability: USD398/50mg (In stock)

Beijing Bode United Chemical Co., Ltd. [email protected] +86 13693519000 China

Fax: +86 (10) 8760-9286Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD96/5mg () USD168/10mg ()

Chongqing Chemieliva Pharmaceutical Co., Ltd. [email protected] 0086-23-67770219 China

Fax: 0086-23-67770220Purity: Brand:

Formosa Laboratories, Inc. [email protected] 886 3 3240895 CHINA

Fax: 886 3 3240923Purity: Brand:

Hydragon Pharma Co., Ltd. [email protected] +86 (21) 5021-5258 / 5021-8972 China

Fax: +86 (21) 5021-5756Purity: Brand:

Manus Aktteva [email protected] +91 (79) 6512-3395 India

Fax: +91 (79) 2646-3395Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD96/5mg () USD168/10mg ()
Quality Control & MSDS Files: NP-HPLC NP-HPLC HNMR HNMR HNMR HNMR NP-HPLC NP-HPLC HNMR NP-HPLC MSDS

Nectar Industrial Co., Ltd. [email protected] +86 (755) 8100-9345 China

Fax: +86 (755) 8225-2078Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD70/2mg (In stock) USD120/5mg (In stock) USD190/10mM/1mLIn DMSO (In stock) USD370/25mg (In stock) USD970/100mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD96/5mg () USD168/10mg ()

Shanghai RenYoung Pharmaceutical Co., Ltd. [email protected] +86 (21) 3501-0877 China

Fax: +86 (21) 3501-0877Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD97/5mg () USD371/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: #97 % Brand: Tocris

Xi'an Fude Technology Co., Ltd. [email protected],[email protected] +86 (29) 8835-2856 China

Fax: +86 (29) 8832-3691Purity: Brand:

Yann Pharmachem Co., Ltd. [email protected] +86 (21) 6522-5530 China

Fax: +86 (21) 6522-5811Purity: Brand:

Zhangjiagang Sunrise Fine Chemical Co., Ltd. [email protected] +86 (574) 8797-0832 China

Fax: +86 (574) 8770-1738Purity: Brand:

Zhejiang Esun Chemical Co., Ltd. [email protected] +86 (571) 5628-6531 China

Fax: +86 (571) 5628-7608Purity: Brand:

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Background Information of Alfacalcidol

Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.

Solubility of Alfacalcidol

Solubility Sources
DMSO ≥78mg/mL Water <1.2mg/mL Ethanol ≥79mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 80 mg/mL (199.68 mM); Ethanol80 mg/mL (199.68 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC
Soluble to 100 mM in DMSO and to 100 mM in ethanol Tocris Bioscience Inc.

Storage Condition of Alfacalcidol

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Store at -20°C Tocris Bioscience Inc.

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[NP-HPLC] [HNMR] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Others
Target VD/VDR
Research Area Metabolic Disease
Indications Hepatitis C virus infection Osteoporosis Secondary hyperparathyroidism

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Alfacalcidol Minapharm Pharmaceuticals Hepatitis C virus infection 2013/6/30 2015/6/30 Phase 4 Clinical
Alfacalcidol Seoul National University Hospital 2013/1/31 2013/3/31 Phase 4 Clinical
Alfacalcidol Eli Lilly Japan KK Osteoporosis 2011/8/31 2011/12/31 Phase 4 Clinical
Alfacalcidol Mahidol University Secondary hyperparathyroidism 2008/8/31 2009/8/31 Phase 4 Clinical
Alfacalcidol - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
400.64 C27H44O2 41294-56-8 1-alpha-Hydroxycholecalciferol; (1alpha,3beta,5Z,7E)-Secocholesta-5,7,10(19)-triene-1,3-diol; (1R,3S,E)-5-((Z)-2-((1R,3aS,7aR)-7a-methyl-1-((R)-6-methylheptan-2-yl)hexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol

Structure Information of Alfacalcidol

Smiles C[[email protected]]([[email protected]@H]([[email protected]](C)CCCC(C)C)CC1)(CCC/2)[[email protected]]1([H])C2=C/C=C(C[[email protected]]3O)/C([[email protected]@H](O)C3)=C
InChI InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11-,22-12+/t19-,23-,24-,25+,26+,27-/m1/s1

Related Products

Other Form Products of Alfacalcidol

Name CAS Formula Suppliers
YYA-021 144217-65-2 C18H27N3O2 12
AZD9362 1905412-80-7 C24H27ClN8O2 3
NT157 1384426-12-3 C16H14BrNO5S 12
MK-4101 935273-79-3 C24H24F5N5O 13
PT-262 86811-36-1 C14H13ClN2O2 2
NSC 663284 383907-43-5 C15H16ClN3O3 12
NSC5844 140926-75-6 C20H16Cl2N4 11
PD 117519 96392-15-3 C19H21N5O4 7
4-Pyridinecarboxamide, 2-chloro-N-[4-(4,5-dihydronaphth[1,2-c]isoxazol-3-yl)phenyl]-6-methoxy-N-methyl- 924765-47-9 C25H20ClN3O3 1
4-Pyridinecarboxamide, 2-chloro-N-[4-(4,5-dihydronaphth[1,2-c]isoxazol-3-yl)phenyl]-6-methoxy- 924731-61-3 C24H18ClN3O3 1

Recommended Products in Same Target

Name CAS Formula Suppliers
25,26-Dihydroxyvitamin D3 29261-12-9 C27H44O3 6
(24R)-MC 976 112828-09-8 C27H42O3 8
(24S)-24,25-Dihydroxyvitamin D3 55700-58-8 C27H44O3 8
Calcitriol Impurities D 103656-40-2 C28H46O3 5
Calcifediol (monohydrate) 63283-36-3 C27H44O2 16
Cholecalciferol 67-97-0 C27H44O 15
(24S)-MC 976 112849-14-6 C27H42O3 9
(1S,4R,E)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-1-cyclopropylpent-2-en-1-ol C39H68O3Si2 5
VD3-D6 118584-54-6 C27H38D6O 5
VD2-D3 1217448-46-8 C28H41D3O 9
25-Hydroxy VD2-D6 1262843-46-8 C28H38D6O2 9
1alpha, 25-Dihydroxy VD2-D6 216244-04-1 C28H38D6O3 9
Calcipotriol (monohydrate) 147657-22-5 C27H42O4 13
Cholecalciferol 67-97-0 C27H44O 12
Calcitriol Impurities A 73837-24-8 C27H44O3 7
(1R,3S,E)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 910133-70-9 C27H40O3 4
Paricalcitol 131918-61-1 C27H44O3 20
MC 976 129831-99-8 C27H42O3 10
24R-Calcipotriol 112827-99-3 C27H40O3 7
MC 1046 126860-83-1 C27H38O3 8

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Name CAS Formula Suppliers
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Danoprevir 850876-88-9 C35H46FN5O9S 16
Toremifene (Citrate) 89778-27-8 C32H36ClNO8 15
Sorafenib (Tosylate) 475207-59-1 C28H24ClF3N4O6S 25
Rilpivirine 500287-72-9 C22H18N6 15
Narlaprevir 865466-24-6 C36H61N5O7S 10
Emricasan 254750-02-2 C26H27F4N3O7 8
Cinacalcet (hydrochloride) 364782-34-3 C22H23ClF3N 15
Odanacatib 603139-19-1 C25H27F4N3O3S 19
MK-0773 606101-58-0 C27H34FN5O2 8
Balapiravir 690270-29-2 C21H30N6O8 8
Cinacalcet 226256-56-0 C22H22F3N 14
Silibinin 22888-70-6 C25H22O10 31
Nesbuvir 691852-58-1 C22H23FN2O5S 11
Clemizole 442-52-4 C19H20ClN3 14
Asunaprevir 630420-16-5 C35H46ClN5O9S 19
Zanamivir 139110-80-8 C12H20N4O7 20
Doxercalciferol 54573-75-0 C28H44O2 10
CTS-1027 193022-04-7 C19H20ClNO6S 10

Safety Data of Alfacalcidol

Hazard Symbols:T+,Xi Risk Statements:26/27/28-36/37/38 Safety Statements:28-36/37-45-36-26
Transport Information: HS Code:29361000 RTECS:VS2851000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white solid Melting point:134-136°C
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:255-297-1
Optical Rotation: alpha: yms1-alpha-Hydroxycholecalciferol; (1alpha,3beta,5Z,7E)-Secocholesta-5,7,10(19)-triene-1,3-diol

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