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RO4929097

(CAS: 847925-91-1)

Suppliers of RO4929097

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BLD Pharmatech [email protected] +86-21-61629022

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD132/5mg () USD240/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD132/5mg () USD240/10mg ()
Quality Control & MSDS Files: HNMR HNMR LCMS NP-HPLC NP-HPLC LCMS MSDS

MedKoo Biosciences, Inc. [email protected]o.com 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD170/5mg (In stock) USD238/10mM/1mLIn DMSO (In stock) USD320/10mg (In stock) USD970/50mg (In stock) USD2470/200mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HNMR HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD132/5mg () USD240/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD78/2mg () USD123/5mg () USD174/10mg () USD268/25mg () USD458/50mg ()

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Background Information of RO4929097

RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. IC50 value: 4 nM Target: γ secretase in vitro: RO4929097 decreases the amount of Aβ peptides secreted into the culture medium in HEK293 cells with EC50 of 14 nM.

Solubility of RO4929097

Solubility Sources
Soluble in DMSO > 10 mM Apexbio Technology LLC
DMSO ≥90mg/mL Water <1.2mg/mL Ethanol ≥14mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 94 mg/mL (200.25 mM); Ethanol16 mg/mL (34.08 mM); Water<1 mg/mL (<1 mM); In vivo 2% DMSO+30% PEG 300+5% Tween+ddH2O10mg/mL Selleck Chemicals LLC

Storage Condition of RO4929097

Storage Condition Sources
Store at -20°C Apexbio Technology LLC

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
RO4929097 National Cancer Institute Metastatic colorectal cancer 2010/12/31 Phase 2 Clinical
RO4929097 National Cancer Institute Multiple myeloma 2010/12/31 2012/7/31 Phase 2 Clinical
RO4929097 University of Colorado at Denver and Health Sciences Center Pancreas tumor 2010/10/31 Phase 2 Clinical
RO4929097 National Cancer Institute Stage III melanoma 2010/9/30 Phase 2 Clinical
RO4929097 National Cancer Institute Stage IV melanoma 2010/9/30 Phase 2 Clinical
RO4929097 National Cancer Institute; The Cancer Institute of New Jersey Prostate tumor 2010/8/31 2012/8/31 Phase 2 Clinical
RO4929097 - Discontinued
RO4929097 - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
469.4 C22H20F5N3O3 847925-91-1 RO-4929097; RO 4929097; (S)-2,2-dimethyl-N1-(6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N3-(2,2,3,3,3-pentafluoropropyl)malonamide

Structure Information of RO4929097

Smiles O=C(C(C)(C(NCC(F)(C(F)(F)F)F)=O)C)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3NC1=O
InChI InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1

Related Products

Other Form Products of RO4929097

Name CAS Formula Suppliers

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gamma-secretase modulator 3 1431697-84-5 C24H23FN4OS 7
BMS 433796 935525-13-6 C19H16F2N4O4 7
BMS 299897 290315-45-6 C24H21ClF3NO4S 15
ELN 318463 851600-86-7 C19H20BrClN2O3S 1
MRK 003 623165-93-5 C25H31F6N3O2S 5
PF-3084014 1290543-63-3 C27H41F2N5O 11
CHF5074 749269-83-8 C16H11Cl2FO2 10
Begacestat 769169-27-9 C9H8ClF6NO3S2 6
gamma-secretase modulator 1 1172637-87-4 C24H24N4OS 7
gamma-secretase modulator 2 1093978-89-2 C25H22F4N6O2 5
LY-411575 209984-57-6 C26H23F2N3O4 17
E 2012 870843-42-8 C25H26FN3O2 9
Semagacestat 425386-60-3 C19H27N3O4 18
DAPT 208255-80-5 C23H26F2N2O4 18
MK-0752 471905-41-6 C21H21ClF2O4S 16
BMS-708163 1146699-66-2 C20H17ClF4N4O4S 16
L-685458 292632-98-5 C39H52N4O6 14
Z-Ile-Leu-aldehyde 161710-10-7 C20H30N2O4 9

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Name CAS Formula Suppliers
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Trametinib 871700-17-3 C26H23FIN5O4 21
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AT9283 896466-04-9 C19H23N7O2 21
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Tivantinib 905854-02-6 C23H19N3O2 10
IDO5L 914471-09-3 C9H7ClFN5O2 16
MLN9708 1239908-20-3 C20H23BCl2N2O9 9
Panobinostat 404950-80-7 C21H23N3O2 21
Dovitinib 405169-16-6 C21H21FN6O 19
SB-590885 405554-55-4 C27H27N5O2 18
Sunitinib 557795-19-4 C22H27FN4O2 19
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Fenretinide 65646-68-6 C26H33NO2 23
Leuprolide (Acetate) 74381-53-6 C61H88N16O14 21
LY2603618 911222-45-2 C18H22BrN5O3 15
ARRY-520 (R enantiomer) 885060-08-2 C20H22F2N4O2S 8
ARRY-520 885060-09-3 C20H22F2N4O2S 14

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,93 mg/mL(198.12 mM);In vitro:Ethanol,16 mg/mL(34.08 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):2% DMSO+30% PEG 300+5% Tween+ddH2OFor best result
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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