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AMG 900

(CAS: 945595-80-2)

Suppliers of AMG 900

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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Active Biopharma Corp [email protected] +86 (571) 8161-2335 China

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 0.98 Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD130/5mg () USD226/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD130/5mg () USD226/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD170/5mg (In stock) USD320/10mg (In stock) USD340/10mM/1mLIn DMSO (In stock) USD970/50mg (In stock) USD2470/200mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD130/5mg () USD226/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD132/10mg () USD365/50mg () USD568/100mg ()

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Background Information of AMG 900

AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2.

Solubility of AMG 900

Solubility Sources
DMSO ≥95mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 100 mg/mL (198.57 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 1% DMSO+30% polyethylene glycol+1% Tween 8020 mg/mL Selleck Chemicals LLC

Storage Condition of AMG 900

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage Epigenetics
Target Aurora Kinase
Research Area Cancer
Indications Leukemia Advanced solid tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AMG 900 Amgen Inc Leukemia 2011/7/31 2014/7/31 Phase 1 Clinical
AMG 900 Amgen Inc Advanced solid tumor 2009/4/30 2013/6/30 Phase 1 Clinical
AMG 900 - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
503.58 C28H21N7OS 945595-80-2 AMG-900;AMG900; N-(4-((3-(2-aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine

Structure Information of AMG 900

Smiles CC1=CSC(C2=NN=C(C3=C2C=CC=C3)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=CC=NC(N)=N6)=C1
InChI InChI=1S/C28H21N7OS/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23/h2-16H,1H3,(H,32,35)(H2,29,31,33)

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Other Form Products of AMG 900

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MLN4924 905579-51-3 C21H25N5O4S 16
SNX-2112 908112-43-6 C23H27F3N4O3 12
ABC294640 915385-81-8 C23H25ClN2O 9
OTSSP167 1431697-89-0 C25H28Cl2N4O2 12
MK-0752 471905-41-6 C21H21ClF2O4S 16
ZSTK474 475110-96-4 C19H21F2N7O2 20
BMS-599626 714971-09-2 C27H27FN8O3 14
PHA-848125 802539-81-7 C25H32N8O 15
17-AAG (Hydrochloride) 911710-03-7 C31H44ClN3O8 7
Veliparib 912444-00-9 C13H16N4O 11
Veliparib (dihydrochloride) 912445-05-7 C13H18Cl2N4O 8

Chemical and Physical Properties

Appearance:Light yellow to yellow solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,100 mg/mL(198.57 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):1% DMSO+30% polyethylene glycol+1% Tween 80For best resul
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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