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SCH 527123

(CAS: 473727-83-2)

Suppliers of SCH 527123

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD168/5mg () USD288/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD168/5mg () USD288/10mg ()
Quality Control & MSDS Files: MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD168/5mg () USD288/10mg ()

Shanghai XingMo Biotechnology Co., Ltd. [email protected] 13524779951 CHINA

Fax: Purity: > 98% Brand: X-MoBio

Price and Availability: USD1300/1g (In stock)

Thompson Biological Technology Co., Ltd. [email protected] +86 (10) 5248-8336 China

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Background Information of SCH 527123

SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively. IC50 value: 42 nM (CXCR1); 3 nM (CXCR2) [1] Target: CXCR1/2 in vitro: Sch527123 inhibits chemokine binding to CXCR1 and CXCR2 receptors in an insurmountable manner and is categorized as an allosteric antagonist.

Solubility of SCH 527123

Solubility Sources
DMSO MedChemexpress Co., Ltd.
DMSO mg/mL (<1 mM) ; Water mg/mL (<1 mM) ; Ethanol mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of SCH 527123

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target CXCR
Research Area Inflammation/Immunology
Indications Chronic obstructive pulmonary disease Asthma Psoriasis

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
SCH 527123 Merck & Co Inc Chronic obstructive pulmonary disease 2009/10/31 2011/11/30 Phase 2 Clinical
SCH 527123 Merck & Co Inc Asthma 2010/1/31 2012/8/31 Phase 2 Clinical
SCH 527123 Merck & Co Inc Asthma 2008/6/30 2009/2/28 Phase 2 Clinical
SCH 527123 Schering-Plough Corp Asthma 2008/5/31 2009/2/28 Phase 2 Clinical
SCH 527123 Merck & Co Inc Psoriasis 2007/6/30 2007/10/31 Phase 2 Clinical
SCH 527123 - Discontinued
SCH 527123 - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
397.42 C21H23N3O5 473727-83-2 SCH-527123;SCH527123; (R)-2-hydroxy-N,N-dimethyl-3-((2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)benzamide

Structure Information of SCH 527123

Smiles O=C1C(C(NC2=CC=CC(C(N(C)C)=O)=C2O)=C1N[[email protected]](CC)C3=CC=C(O3)C)=O
InChI InChI=1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1

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Chemical and Physical Properties

Appearance:Light yellow to yellow solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:>19.9mg/mL in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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