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Diazepam

(CAS: 439-14-5)

Suppliers of Diazepam

Company Name Email Tel Country
Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Changzhou Anyi Biochem Co., Ltd. [email protected] +86 (519) 8883-6158 China

Fax: Purity: Brand:

Changzhou Kangzheng Pharmachem Technology Co., Ltd. [email protected] +86 (519) 8510-9938 China

Fax: +86 (519) 8510-9937Purity: Brand:

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of Diazepam

Diazepam(Ro 5-2807), a long-acting "classical" benzodiazepine, is a positive allosteric modulators of the GABA type A receptors. IC50 value: Target: GABAA receptor Diazepam possesses anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties.

Solubility of Diazepam

Solubility Sources
Soluble to 100 mM in DMSO and to 25 mM in ethanol Tocris Bioscience Inc.

Storage Condition of Diazepam

Storage Condition Sources
Store at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel Neuronal Signaling
Target GABA Receptor
Research Area Neurological Disease
Indications Status epilepticus Epilepsy Pain

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Diazepam National Institute of Neurological Disorders and Stroke Status epilepticus 1995/11/30 1999/2/01 Phase 3 Clinical
Diazepam Pfizer Inc Epilepsy 2006/1/31 2013/7/31 Phase 3 Clinical
Diazepam University of Missouri Pain 2013/9/30 2014/8/01 Phase 2 Clinical
Diazepam National Institute of Nursing Research Pain 2005/7/31 2006/2/01 Phase 2 Clinical
Diazepam - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
284.74 C16H13ClN2O 439-14-5 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; 7-chloro-1-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one

Structure Information of Diazepam

Smiles CN1C(C=C2)=C(C=C2Cl)C(C3=CC=CC=C3)=NCC1=O
InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

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Chemical and Physical Properties

Appearance:White to off-white solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:DMSO:28.47mg/mL;100mM;ethanol:7.12mg/mL;25mM;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:207-122-5
Optical Rotation: alpha:

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