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Tamibarotene

(CAS: 94497-51-5)

Suppliers of Tamibarotene

Company Name Email Tel Country
AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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Astatech, Inc. [email protected] +1 (215) 785-3197 USA

Fax: +1 (215) 785-2656Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Beijing Bode United Chemical Co., Ltd. [email protected] +86 13693519000 China

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/10mg () USD104/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Chengdu D-Innovation Pharmaceutical Co., Ltd. [email protected] +86 (28) 8540-0797 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/10mg () USD104/50mg ()

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD97/50mg (In stock)
Quality Control & MSDS Files: HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/10mg () USD104/50mg ()

Shanghai Hengrui International Trading Co., Ltd. [email protected] +86 (21) 5981-1275 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD44/10mg () USD78/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Yizheng East Chemical Co., Ltd. [email protected],[email protected] +86 (514) 8796-1069 China

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Background Information of Tamibarotene

Tamibarotene(Am-80) is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro.

Solubility of Tamibarotene

Solubility Sources
(25°C) * In vitro DMSO 70 mg/mL (199.18 mM); Ethanol70 mg/mL (199.18 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC
Soluble to 100 mM in 1.1eq. NaOH and to 50 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Tamibarotene

Storage Condition Sources
Store at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[HPLC] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tamibarotene St Marianna University School of Medicine Tropical spastic paraparesis 2011/1/31 2012/3/31 Phase 3 Clinical
Tamibarotene CytRx Corp Metastatic non small cell lung cancer 2011/4/30 2013/6/30 Phase 2 Clinical
Tamibarotene Kinki University Lupus nephritis 2010/9/30 2013/2/28 Phase 2 Clinical
Tamibarotene Osaka City University Alzheimers disease 2010/5/31 2012/12/31 Phase 2 Clinical
Tamibarotene National Institute of Cancerología Carcinoma 2007/9/30 2009/11/30 Phase 2 Clinical
Tamibarotene National Institute of Cancerología Non-small-cell lung cancer 2007/9/30 2009/11/30 Phase 2 Clinical
Tamibarotene - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
351.44 C22H25NO3 94497-51-5 Am80;Am 80;Am-80; 4-((5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl)benzoic acid

Structure Information of Tamibarotene

Smiles O=C(C1=CC=C(C=C1)C(NC2=CC=C3C(C)(CCC(C)(C3=C2)C)C)=O)O
InChI InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:231-232°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,70 mg/mL(199.18 mM);In vitro:Ethanol,70 mg/mL(199.18 mM);In vitro:Water,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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