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AZD1152

(CAS: 722543-31-9)

Suppliers of AZD1152

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand: AOBIOUS INC

Price and Availability: USD36/1mg ()

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD144/5mg () USD240/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD144/5mg () USD240/10mg ()
Quality Control & MSDS Files: HNMR HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD144/5mg () USD240/10mg ()

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Background Information of AZD1152

AZD1152 is a pro-drug of Barasertib-hQPA, which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.

Solubility of AZD1152

Solubility Sources
DMSO > 80 mg/ml Water MedChemexpress Co., Ltd.

Storage Condition of AZD1152

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Cell Cycle/DNA Damage Epigenetics
Target Aurora Kinase
Research Area Cancer
Indications Diffuse large B-cell lymphoma Acute myelogenous leukemia Solid tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
AZD1152 University of Oxford Diffuse large B-cell lymphoma 2011/9/30 2014/9/30 Phase 2 Clinical
AZD1152 AstraZeneca plc Acute myelogenous leukemia 2006/5/31 2010/4/30 Phase 2 Clinical
AZD1152 AstraZeneca plc Acute myelogenous leukemia 2009/11/30 2010/6/01 Phase 1 Clinical
AZD1152 AstraZeneca plc Acute myelogenous leukemia 2009/6/30 2011/5/31 Phase 1 Clinical
AZD1152 AstraZeneca plc Solid tumor 2006/8/31 2007/7/31 Phase 1 Clinical
AZD1152 - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
587.54 C26H31FN7O6P 722543-31-9 Barasertib

Structure Information of AZD1152

Smiles O=C(NC1=CC=CC(F)=C1)CC2=CC(NC3=C4C=CC(OCCCN(CC)CCOP(O)(O)=O)=CC4=NC=N3)=NN2
InChI InChI=1S/C26H31FN7O6P/c1-2-34(10-12-40-41(36,37)38)9-4-11-39-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(35)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17H,2,4,9-12,15H2,1H3,(H,30,35)(H2,36,37,38)(H2,28,29,31,32,33)

Related Products

Other Form Products of AZD1152

Name CAS Formula Suppliers
WAY 200070 440122-66-7 C13H8BrNO3 5
ST034307 133406-29-8 C10H4Cl4O2 10
Thiomyristoyl 1429749-41-6 C34H51N3O3S 8
Vadadustat 1000025-07-9 C14H11ClN2O4 8
AZD-1236 459814-89-2 C15H19ClN4O5S 3
1-Butanol, 4-[[4-(3,4-dichlorophenyl)-1,2,5-thiadiazol-3-yl]oxy]- 1638526-21-2 C12H12Cl2N2O2S 1
(3α,5β,6β,7α)-BAR501 1632118-70-7 C26H46O3 4
BAR501 1632118-69-4 C26H46O3 10
BAR502 1612191-86-2 C25H44O3 8
GDC-0326 1282514-88-8 C19H22N6O3 11
STK16-IN-1 1223001-53-3 C17H12FN3O 8

Recommended Products in Same Target

Name CAS Formula Suppliers
TAK-632 1228591-30-7 C27H18F4N4O3S 22
XL228 898280-07-4 C22H31N9O 16
MK-8745 885325-71-3 C20H19ClFN5OS 17
ENMD-2076 934353-76-1 C21H25N7 16
ABT-348 1227939-82-3 C25H21FN6O2S 8
Reversine 656820-32-5 C21H27N7O 22
PF-03814735 942487-16-3 C23H25F3N6O2 18
MK-5108 1010085-13-8 C22H21ClFN3O3S 22
CCT 137690 1095382-05-0 C26H31BrN8O 16
SCH-1473759 (hydrochloride) 1094067-13-6 C20H27ClN8OS 6
SCH-1473759 1094069-99-4 C20H26N8OS 11
AMG 900 945595-80-2 C28H21N7OS 16
TAK-901 934541-31-8 C28H32N4O3S 15
Hesperadin 422513-13-1 C29H32N4O3S 10
ENMD-2076 (Tartrate) 1291074-87-7 C25H31N7O6 10
CCT129202 942947-93-5 C23H25ClN8OS 14
PHA-680632 398493-79-3 C28H35N7O2 15
JNJ-7706621 443797-96-4 C15H12F2N6O3S 18
AZD1152-HQPA 722544-51-6 C26H30FN7O3 16
Danusertib 827318-97-8 C26H30N6O3 10

Recommended Products in the Same Indication

Name CAS Formula Suppliers
AZD1152-HQPA 722544-51-6 C26H30FN7O3 16
Mocetinostat 726169-73-9 C23H20N6O 18
Volasertib 755038-65-4 C34H50N8O3 17
PU-H71 873436-91-0 C18H21IN6O2S 9
BMS-599626 (Hydrochloride) 873837-23-1 C27H28ClFN8O3 12
AT9283 896466-04-9 C19H23N7O2 21
KX2-391 897016-82-9 C26H29N3O3 14
MLN4924 905579-51-3 C21H25N5O4S 16
SNX-2112 908112-43-6 C23H27F3N4O3 12
Nordihydroguaiaretic acid 500-38-9 C18H22O4 17
Pazopanib (Hydrochloride) 635702-64-6 C21H24ClN7O2S 19
RX-3117 865838-26-2 C10H12FN3O4 8
Crenolanib 670220-88-9 C26H29N5O2 16
OSU-03012 742112-33-0 C26H19F3N4O 12
Motesanib (Diphosphate) 857876-30-3 C22H29N5O9P2 20
LY2603618 911222-45-2 C18H22BrN5O3 15
AT13387 912999-49-6 C24H31N3O3 19
ARRY-520 (R enantiomer) 885060-08-2 C20H22F2N4O2S 8
ARRY-520 885060-09-3 C20H22F2N4O2S 14
Dasatinib (hydrochloride) 854001-07-3 C22H27Cl2N7O2S 10

Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:>5.9mg/mL in DMSO
Density:1.463 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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