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Wortmannin

(CAS: 19545-26-7)

Suppliers of Wortmannin

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AbMole BioScience [email protected] 1-800-660-8580 USA

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Abcam [email protected] (888) 77-ABCAM (22226) USA

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Price and Availability: USD70/1mg () USD233/5mg ()

Acros Organics [email protected] +86 (21) 5258-1100 Belgium

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Adipogen Corporation [email protected] (858) 457-8383 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Apollo Scientific Ltd. [email protected] +44 (161) 406-0505 United Kingdom

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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Biomol GmbH [email protected] +49 (0)40 8532600 0800 2466651 kostenfrei Germany

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD96/5mg () USD132/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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EMD Millipore USA

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Enzo Life Sciences International Inc. [email protected] +1 (610) 941-0430 USA

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Price and Availability: USD56/1mg () USD223/5mg () USD422/20mg ()

Fermentek Ltd [email protected] 972-2-5853953 Australia

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Fluorochem [email protected] (+44) 1457 860 111 United Kingdom

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J&K Scientific Ltd. [email protected];[email protected] 400-666-7788 / +86 10 8284 8833 China

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Price and Availability: RMB630/1mg () RMB1400/5mg () RMB2310/10mg () RMB3500/20mg () RMB4130/25mg ()

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: Brand:

Price and Availability: USD27/10mg (In stock) USD59/25mg (In stock) USD111/50mg (In stock) USD206/100mg (In stock) USD525/300mg (In stock) USD845/500mg (In stock) USD1635/1g (In stock)

MAYA-R [email protected] 40066-10775 China

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Price and Availability: RMB980/5mg () RMB2880/25mg () RMB7680/100mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD96/5mg () USD132/10mg ()
Quality Control & MSDS Files: HNMR HNMR LCMS LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Price and Availability: USD55/1mg () USD205/5mg () USD399/20mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD110/5mg (In stock) USD170/10mg (In stock) USD176/10mM/1mLIn DMSO (In stock) USD176/10mM*1mLIn DMSO () USD270/20mg (In stock)
Quality Control & MSDS Files: HPLC HPLC HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD96/5mg () USD132/10mg ()

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Price and Availability: USD82/1mg () USD268/5mg () USD537/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD88/5mg () USD126/10mg () USD222/20mg () USD372/50mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

Price and Availability: USD89/1mg () USD329/5mg ()

Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

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Price and Availability: USD274/20mg ()

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Background Information of Wortmannin

Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 0.17 μM and 3 nM, respectively.

Solubility of Wortmannin

Solubility Sources
10 mM in DMSO CHEMSCENE, LLC
Soluble in DMSO or ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
10 mM in DMSO MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 85 mg/mL (198.39 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 1% DMSO+30% polyethylene glycol+1% Tween 808 mg/mL Selleck Chemicals LLC

Storage Condition of Wortmannin

Storage Condition Sources
Store at or below -20 oC. LC Laboratoies
4°C MedChemexpress Co., Ltd.
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways PI3K/Akt/mTOR Cell Cycle/DNA Damage
Target DNA-PK PI3K ATM/ATR
Research Area Cancer
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Wortmannin - Not Found
Wortmannin - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
428.43 C23H24O8 19545-26-7 (+)-Wortmannin; KY 1242; [1S-(1alpha,6balpha,9abeta,11alpha,11bbeta)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9; (1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate

Structure Information of Wortmannin

Smiles C[[email protected]@](C(C1=CO2)=C2C3=O)([[email protected]@H](COC)OC1=O)C4=C3[[email protected]@](CCC5=O)([H])[[email protected]]5(C)C[[email protected]]4OC(C)=O
InChI InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

Related Products

Other Form Products of Wortmannin

Name CAS Formula Suppliers
Deoxypseudouridine 39967-60-7 C9H12N2O5 6
BMS-852927 1256918-39-4 C29H28Cl2F2N2O4S 6
AZ PFKFB3 67 1704741-11-6 C26H25N5O3 3
AZ PFKFB3 26 1704740-52-2 C24H26N4O2 3

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Safety Data of Wortmannin

Hazard Symbols:T+,T,Xi,Xn,F Risk Statements:R11;R20/21/22;R36 Safety Statements:S16;S36/37
Transport Information:UN 1648 3 / PGII HS Code: RTECS:CB9641000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:234-240 °C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,85 mg/mL(198.39 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+40% PEG 300+5% Tween 80+ddH2OFor best results, use
Density:1.39±0.1 g/cm3 (20 ºC 760 Torr), Calc.* Merck:13,10110
BRN: Refractive Index:
Vapour: EINECS:214-538-0
Optical Rotation: alpha: yms(+)-Wortmannin; KY 1242; [1S-(1alpha,6balpha,9abeta,11alpha,11bbeta)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,

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