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LY451395

(CAS: 375345-95-2)

Suppliers of LY451395

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD420/5mg () USD600/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD420/5mg () USD600/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD420/5mg () USD600/10mg ()

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Background Information of LY451395

LY451395(Mibampator) is a potent and highly selective potentiator of the AMPA receptors. IC50 value: Target: AMPA receptor potentiator in vitro: in vivo: Incubation of LY451395 with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1].

Solubility of LY451395

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of LY451395

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel Neuronal Signaling
Target iGluR
Research Area Neurological Disease
Indications Alzheimer's Disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
LY451395 Eli Lilly and Company Alzheimer's Disease 2009/2/12 Phase 2 Clinical
LY451395 Eli Lilly and Company Alzheimer's Disease 2003/1/17 Phase 2 Clinical
LY451395 - Phase 2

Chemical Information

M.Wt Formula CAS No. Synonyms
438.6 C21H30N2O4S2 375345-95-2 Mibampator;LY 451395;LY-451395; (R)-N-(2-(4'-(2-(methylsulfonamido)ethyl)-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide

Structure Information of LY451395

Smiles C[[email protected]@H](CNS(C(C)C)(=O)=O)C1=CC=C(C2=CC=C(CCNS(C)(=O)=O)C=C2)C=C1
InChI InChI=1S/C21H30N2O4S2/c1-16(2)29(26,27)23-15-17(3)19-9-11-21(12-10-19)20-7-5-18(6-8-20)13-14-22-28(4,24)25/h5-12,16-17,22-23H,13-15H2,1-4H3/t17-/m0/s1

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:Soluble in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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