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Genistein

(CAS: 446-72-0)

Suppliers of Genistein

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AA Blocks LLC [email protected] +1 858-523-8231

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ALB Technology Limited [email protected] China

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AOBIOUS INC [email protected] (508) 306-0937 USA

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AOBIOUS INC [email protected] (508) 306-0937 USA

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AbMole BioScience [email protected] 1-800-660-8580 USA

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Abcam [email protected] (888) 77-ABCAM (22226) USA

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Adipogen Corporation [email protected] (858) 457-8383 USA

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Affix Scientific [email protected] +1-510-936-6647 USA

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Quality Control & MSDS Files: CoA MSDS

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Carbosynth Limited [email protected] +44 (1635) 578-444

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Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Chengdu Tianyuan Natural Product Co., Ltd. [email protected],[email protected] +86 (28) 8501-2281 / +86 13808177790 China

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EMD Millipore USA

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Hangzhou Bm Chemical Co., Ltd. [email protected] +86 (571) 8733-0289 China

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Hangzhou Hennychem Material Co., Ltd. [email protected],[email protected] +86 (571) 8269-3023 China

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J & W PharmLab LLC [email protected] +1 (215) 945-6595 USA

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LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

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Price and Availability: USD59/1g (In stock) USD152/5g (In stock) USD245/10g (In stock) USD445/25g (In stock) USD785/50g (In stock) USD1175/100g (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD60/100mg () USD106/500mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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N&R Industries, Inc. [email protected],[email protected],[email protected] +86 (29) 8876-4861 China

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Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD70/25mg (In stock) USD90/10mM/1mLIn DMSO (In stock) USD110/50mg (In stock) USD170/100mg (In stock)
Quality Control & MSDS Files: HPLC HPLC

Shaanxi Green Bio-Engineering Co., Ltd. [email protected],[email protected] +86 (29) 8621-5910 / 8621-5920 / 8621-5930 China

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Shaanxi Scidoor Hi-Tech Biology Co., Ltd. [email protected] +86 (29) 6296-0300 / 6296-0309 / 6296-0305 China

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Shaanxi Sciphar Biotechnology Co., Ltd. [email protected] +86 (29) 8835-3228 / 8838-9752 / 8300-6195 China

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Shaanxi Tianrun Phytochemical Co., Ltd. [email protected] +86 (29) 8839-0044 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Shannxi Huike Botanical Development Co., Ltd. [email protected] +86 (29) 6266-9896 / 6266-9893 / 6266-9894 China

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Sichuan Xieli Pharmaceutical Co., Ltd. [email protected] +86 (28) 8371-5511 / 8375-8578 China

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Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Spectrum Chemical Mfg. Corp. [email protected] +1 (310) 516-8000 USA

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

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Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

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Toronto Research Chemicals Inc. [email protected] +1 (416) 665-9696 Canada

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Xi'an Sino-Herb Bio-technology Co., Ltd. [email protected] +86 (29) 8833-0278 / 8833-0490 China

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Xi'an Union Pharmpro Co., Ltd. [email protected] +86 (29) 8886-5676 China

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Background Information of Genistein

Genistein(NPI 031L), a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. IC50 Value: It has been shown that genistein inhibits many type of cancers including prostate cancer (PCa) by regulating several cell signaling pathways and microRNAs (miRNAs). in vitro: GEN effectively reversed estrogenicity of BPA by reversing mRNA and protein expressions of ERα, IGF-1R, pIRS-1, and pAkt induced by BPA in cellular model and also significantly decreased tumor growth and in vivo expressions of ERα, pIRS-1, and pAkt in xenografted mouse model [1].

Solubility of Genistein

Solubility Sources
Soluble in DMSO. LC Laboratoies
DMSO 54 mg/ml; Water <1 mg/ml MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 54 mg/mL (199.82 mM); Ethanol2 mg/mL (7.4 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Genistein

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Store at or below -20 oC. LC Laboratoies

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Genistein Coronary artery disease 1999/10/31 2003/4/01 Phase 3 Clinical
Genistein University of Messina Menopause 2003/1/31 2005/6/30 Phase 3 Clinical
Genistein University of Messina Osteopenia 2003/1/31 2005/6/30 Phase 3 Clinical
Genistein National Center for Complementary and Alternative Medicine 2004/3/31 Phase 3 Clinical
Genistein University of Messina Metabolic syndrome X 2008/9/30 2011/1/31 Phase 3 Clinical
Genistein National Cancer Institute Prostate tumor 2011/12/31 2013/12/31 Phase 2 Clinical
Genistein - Phase 1 Clinical
Genistein - Phase 4

Chemical Information

M.Wt Formula CAS No. Synonyms
270.24 C15H10O5 446-72-0 4',5,7-Trihydroxyisoflavone; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one

Structure Information of Genistein

Smiles O=C1C(C(O)=C2)=C(C=C2O)OC=C1C3=CC=C(O)C=C3
InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

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Safety Data of Genistein

Hazard Symbols:Xi,Xn Risk Statements:36/38-22 Safety Statements:S24/25
Transport Information: HS Code: RTECS:NR2392000
WGK Germany:3

Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:297-298 °C
Boiling point: Flash Point:
Water Solubility: insoluble Solubility:In vitro:DMSO,54 mg/mL(199.82 mM);In vitro:Ethanol,2 mg/mL(7.4 mM);In vitro:Water,Insoluble;
Density: Merck:14,4391
BRN:263823 Refractive Index:
Vapour: EINECS:207-174-9
Optical Rotation: alpha:

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